Quantitative Pharmacodynamic Characterization of Resistance versus Heteroresistance of Colistin in E. coli Using a Semimechanistic Modeling of Killing Curves.
PK/PD modeling
colistin
heteroresistance
pharmacodynamics
pharmacokinetics
polymyxin
Journal
Antimicrobial agents and chemotherapy
ISSN: 1098-6596
Titre abrégé: Antimicrob Agents Chemother
Pays: United States
ID NLM: 0315061
Informations de publication
Date de publication:
20 09 2022
20 09 2022
Historique:
pubmed:
31
8
2022
medline:
24
9
2022
entrez:
30
8
2022
Statut:
ppublish
Résumé
Heteroresistance corresponds to the presence, in a bacterial isolate, of an initial small subpopulation of bacteria characterized by a significant reduction in their sensitivity to a given antibiotic. Mechanisms of heteroresistance versus resistance are poorly understood. The aim of this study was to explore heteroresistance in
Identifiants
pubmed: 36040146
doi: 10.1128/aac.00793-22
pmc: PMC9487539
doi:
Substances chimiques
Anti-Bacterial Agents
0
Escherichia coli Proteins
0
MCR-1 protein, E coli
0
Colistin
Z67X93HJG1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0079322Subventions
Organisme : Biotechnology and Biological Sciences Research Council
Pays : United Kingdom
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