Microvascular capillaroscopic abnormalities and occurrence of antinuclear autoantibodies in patients with sarcoidosis.
Antinuclear antibodies
Microcirculation
Microscopic angioscopy
Sarcoidosis
Journal
Rheumatology international
ISSN: 1437-160X
Titre abrégé: Rheumatol Int
Pays: Germany
ID NLM: 8206885
Informations de publication
Date de publication:
12 2022
12 2022
Historique:
received:
27
06
2022
accepted:
13
08
2022
pubmed:
31
8
2022
medline:
12
10
2022
entrez:
30
8
2022
Statut:
ppublish
Résumé
We described nailfold videocapillaroscopy (NVC) findings and estimated the prevalence of serum anti-nuclear (ANA) and extractable nuclear antigen autoantibodies (ENA) in a cohort of sarcoidosis patients, comparing them with adequate healthy controls (HCs) and with primary Raynaud's phenomenon patients (PRPs). NVC findings were also correlated with the occurrence of autoantibodies, current treatment, laboratory parameters, variables of lung function and whole-body imaging data. Twenty-six patients with sarcoidosis were assessed through NVC, laboratory parameters, pulmonary function tests, chest-X ray and 18- fluorodeoxyglucose positron emission tomography/computed tomography. The NVC parameters and ANA/ENA dosage were recorded also in 30 PRPs and 30 HCs. Sarcoidosis patients showed a higher rate of capillary dilations and nonspecific abnormalities and a lower mean capillary absolute number than PRPs and HCs (p < 0.01 for all comparisons). The prevalence of ANA positivity was higher in patients with sarcoidosis compared with PRPs and HCs (p < 0.02 for both), whereas ENA positivity was detected in one sarcoidosis patient (Ro52). Among sarcoidosis patients, the mean capillary absolute number negatively correlated with the C-reactive protein concentrations and was positively associated with the forced vital capacity percentage. Instead, a negative correlation was detected between serum ACE levels and the presence of capillary dilations (all p < 0.05). Our findings suggest a microvascular involvement in sarcoidosis whose investigation by NVC might be useful for the follow-up of patients displaying RP. Autoantibody positivity in sarcoidosis might suggest autoimmune implications in the disease or the production of autoantibodies reactive to tissue damage.
Identifiants
pubmed: 36040491
doi: 10.1007/s00296-022-05190-5
pii: 10.1007/s00296-022-05190-5
pmc: PMC9548476
doi:
Substances chimiques
Antigens, Nuclear
0
Autoantibodies
0
C-Reactive Protein
9007-41-4
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2199-2210Informations de copyright
© 2022. The Author(s).
Références
Clin Rheumatol. 2018 Oct;37(10):2833-2838
pubmed: 29936689
Br Med J. 1961 Nov 4;2(5261):1165-72
pubmed: 14497750
Semin Arthritis Rheum. 2000 Apr;29(5):328-31
pubmed: 10805357
Reumatismo. 2004 Oct-Dec;56(4):278-81
pubmed: 15643482
Microvasc Res. 2018 Jul;118:113-120
pubmed: 29544760
Adv Exp Med Biol. 2015;866:61-9
pubmed: 26022899
Microvasc Res. 2019 Sep;125:103881
pubmed: 31075243
Autoimmun Rev. 2020 Mar;19(3):102458
pubmed: 31927087
Autoimmune Dis. 2014;2014:351852
pubmed: 25580285
Ann Rheum Dis. 1988 Apr;47(4):337-9
pubmed: 3259126
Adv Exp Med Biol. 2017;980:1-9
pubmed: 28132132
Microvasc Res. 2022 Jul;142:104367
pubmed: 35364109
Autoimmun Rev. 2018 Apr;17(4):344-352
pubmed: 29427827
Multidiscip Respir Med. 2013 Feb 05;8(1):8
pubmed: 23384173
Front Immunol. 2020 Jan 08;10:2933
pubmed: 31969879
Transl Lung Cancer Res. 2019 Jun;8(3):208-213
pubmed: 31367534
Front Immunol. 2020 Jul 14;11:1443
pubmed: 32760396
Clin Exp Med. 2022 May;22(2):277-283
pubmed: 34191227
Angiology. 2018 Nov;69(10):878-883
pubmed: 29747515
Virchows Arch. 1998 Jan;432(1):61-5
pubmed: 9463589
Respirology. 2011 Jan;16(1):69-77
pubmed: 20920145
Virchows Arch A Pathol Anat Histopathol. 1991;418(4):361-8
pubmed: 1850897
Respir Res. 2018 Sep 24;19(1):186
pubmed: 30249259
Rheumatol Int. 2020 Feb;40(2):295-301
pubmed: 31451935
Arthritis Res Ther. 2021 Jun 27;23(1):175
pubmed: 34176504
J Autoimmun. 2014 Feb-Mar;48-49:60-5
pubmed: 24491823
Eur J Clin Invest. 2021 Aug;51(8):e13572
pubmed: 33851422
J Rheumatol. 2019 Sep;46(9):1061-1063
pubmed: 31474612
Nat Rev Dis Primers. 2019 Jul 4;5(1):45
pubmed: 31273209
Autoimmun Rev. 2019 Nov;18(11):102394
pubmed: 31520797
Nat Rev Rheumatol. 2021 Nov;17(11):665-677
pubmed: 34561652
Autoimmun Rev. 2021 May;20(5):102796
pubmed: 33722750
Chest. 2018 Jun;153(6):1432-1442
pubmed: 29224832
Chest. 2010 Jan;137(1):156-63
pubmed: 19741061
Sarcoidosis Vasc Diffuse Lung Dis. 2014 Apr 18;31(1):19-27
pubmed: 24751450
Rheumatol Int. 2022 Aug;42(8):1355-1361
pubmed: 34076720
Cells. 2021 Dec 26;11(1):
pubmed: 35011621
Rheumatol Int. 2015 Nov;35(11):1917-24
pubmed: 26248533
Clin Mol Allergy. 2015 Sep 01;13(1):19
pubmed: 26330764
N Engl J Med. 2021 Sep 9;385(11):1018-1032
pubmed: 34496176
Am J Respir Crit Care Med. 2020 Apr 15;201(8):e26-e51
pubmed: 32293205
Microcirculation. 2018 May;25(4):e12447
pubmed: 29527781
Semin Arthritis Rheum. 2000 Aug;30(1):33-46
pubmed: 10966211
Adv Exp Med Biol. 2015;852:59-69
pubmed: 25753554
J Clin Invest. 1981 Jan;67(1):86-92
pubmed: 6969734