Spatiotemporal characterization of cellular tau pathology in the human locus coeruleus-pericoerulear complex by three-dimensional imaging.
Alzheimer’s disease
Locus coeruleus
Tau pathology
Three-dimensional, iDISCO, light sheet fluorescence microscopy
Journal
Acta neuropathologica
ISSN: 1432-0533
Titre abrégé: Acta Neuropathol
Pays: Germany
ID NLM: 0412041
Informations de publication
Date de publication:
10 2022
10 2022
Historique:
received:
01
06
2022
accepted:
29
07
2022
revised:
28
07
2022
pubmed:
31
8
2022
medline:
15
9
2022
entrez:
30
8
2022
Statut:
ppublish
Résumé
Tau pathology of the noradrenergic locus coeruleus (LC) is a hallmark of several age-related neurodegenerative disorders, including Alzheimer's disease. However, a comprehensive neuropathological examination of the LC is difficult due to its small size and rod-like shape. To investigate the LC cytoarchitecture and tau cytoskeletal pathology in relation to possible propagation patterns of disease-associated tau in an unprecedented large-scale three-dimensional view, we utilized volume immunostaining and optical clearing technology combined with light sheet fluorescence microscopy. We examined AT8
Identifiants
pubmed: 36040521
doi: 10.1007/s00401-022-02477-6
pii: 10.1007/s00401-022-02477-6
pmc: PMC9468059
doi:
Substances chimiques
tau Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
651-676Informations de copyright
© 2022. The Author(s).
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