PrkA is an ATP-dependent protease that regulates sporulation in Bacillus subtilis.
ATPase
Bacillus subtilis
Lon protease
PrkA
phosphorylation
sporulation
Journal
The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R
Informations de publication
Date de publication:
10 2022
10 2022
Historique:
received:
10
02
2022
revised:
15
08
2022
accepted:
16
08
2022
pubmed:
31
8
2022
medline:
3
11
2022
entrez:
30
8
2022
Statut:
ppublish
Résumé
In Bacillus subtilis, sporulation is a sequential and highly regulated process. Phosphorylation events by histidine kinases are key points in the phosphorelay that initiates sporulation, but serine/threonine protein kinases also play important auxiliary roles in this regulation. PrkA has been proposed to be a serine protein kinase expressed during the initiation of sporulation and involved in this differentiation process. Additionally, the role of PrkA in sporulation has been previously proposed to be mediated via the transition phase regulator ScoC, which in turn regulates the transcriptional factor σ
Identifiants
pubmed: 36041628
pii: S0021-9258(22)00879-1
doi: 10.1016/j.jbc.2022.102436
pmc: PMC9512850
pii:
doi:
Substances chimiques
ATP-Dependent Proteases
EC 3.4.21.-
Bacterial Proteins
0
Protein Serine-Threonine Kinases
EC 2.7.11.1
PrkA protein, Bacillus subtilis
EC 2.7.11.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
102436Informations de copyright
Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Conflict of interest The authors declare that they have no conflicts of interest with the contents of this article.