To Rb or Not to Rb: Uncovering Unique Subsets of Small Cell Lung Carcinoma.
Journal
Clinical cancer research : an official journal of the American Association for Cancer Research
ISSN: 1557-3265
Titre abrégé: Clin Cancer Res
Pays: United States
ID NLM: 9502500
Informations de publication
Date de publication:
01 11 2022
01 11 2022
Historique:
received:
02
08
2022
revised:
15
08
2022
accepted:
19
08
2022
pubmed:
1
9
2022
medline:
3
11
2022
entrez:
31
8
2022
Statut:
ppublish
Résumé
The use of IHC as a surrogate for specific underlying genomic alterations has allowed for increasingly comprehensive and accurate diagnosis of small cell lung carcinoma (SCLC). This is especially relevant in light of the increasing recognition of the biologic heterogeneity of this aggressive and difficult-to-treat lung tumor. Integrated genomic and IHC profiling of Rb status in SCLC yields new diagnostic insights and has translational implications. See related article by Febres-Aldana et al., p. 4702.
Identifiants
pubmed: 36044394
pii: 708945
doi: 10.1158/1078-0432.CCR-22-2187
doi:
Types de publication
Editorial
Comment
Langues
eng
Sous-ensembles de citation
IM
Pagination
4603-4605Subventions
Organisme : NCI NIH HHS
ID : K08 CA270077
Pays : United States
Commentaires et corrections
Type : CommentOn
Informations de copyright
©2022 American Association for Cancer Research.