Pharmacological activation of PPARβ/δ preserves mitochondrial respiratory function in ischemia/reperfusion

Animals Fatty Acids / metabolism Ischemia PPAR delta / agonists PPAR-beta / agonists Rats Reactive Oxygen Species / metabolism Reperfusion Respiration
PPARβ/δ ROS cardioprotection electron transport system fatty acid oxidation ischemia/reperfusion mitochondrial respiration

Journal

Frontiers in endocrinology
ISSN: 1664-2392
Titre abrégé: Front Endocrinol (Lausanne)
Pays: Switzerland
ID NLM: 101555782

Informations de publication

Date de publication:
2022
Historique:
received: 11 05 2022
accepted: 21 07 2022
entrez: 1 9 2022
pubmed: 2 9 2022
medline: 9 9 2022
Statut: epublish

Résumé

Myocardial ischemia/reperfusion (I/R) injury leads to significant impairment of cardiac function and remains the leading cause of morbidity and mortality worldwide. Activation of peroxisome proliferator-activated receptor β/δ (PPARβ/δ) confers cardioprotection

Identifiants

DOI: 10.3389/fendo.2022.941822 PMID: 36046786 PMC: PMC9420994
pubmed: 36046786
doi: 10.3389/fendo.2022.941822
pmc: PMC9420994
doi:

Substances chimiques

Fatty Acids 0
PPAR delta 0
PPAR-beta 0
Reactive Oxygen Species 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

941822

Informations de copyright

Copyright © 2022 Papatheodorou, Makrecka-Kuka, Kuka, Liepinsh, Dambrova and Lazou.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Ioanna Papatheodorou (I)

Laboratory of Animal Physiology, Department of Zoology, School of Biology, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Marina Makrecka-Kuka (M)

Laboratory of Pharmaceutical Pharmacology, Latvian Institute of Organic Synthesis, Riga, Latvia.

Janis Kuka (J)

Laboratory of Pharmaceutical Pharmacology, Latvian Institute of Organic Synthesis, Riga, Latvia.

Edgars Liepinsh (E)

Laboratory of Pharmaceutical Pharmacology, Latvian Institute of Organic Synthesis, Riga, Latvia.

Maija Dambrova (M)

Laboratory of Pharmaceutical Pharmacology, Latvian Institute of Organic Synthesis, Riga, Latvia.
Faculty of Pharmacy, Riga Stradins University, Riga, Latvia.

Antigone Lazou (A)

Laboratory of Animal Physiology, Department of Zoology, School of Biology, Aristotle University of Thessaloniki, Thessaloniki, Greece.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Pharmacological activation of PPARβ/δ...
questionsmedicales.fr › Lipides › Acides gras › Pharmacological activation of PPARβ/δ...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Ischémie › Pharmacological activation of PPARβ/δ...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Récepteurs cytoplasmiques et nucléaires › Récepteur PPAR delta › Pharmacological activation of PPARβ/δ...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Récepteurs cytoplasmiques et nucléaires › Récepteur PPAR bêta › Pharmacological activation of PPARβ/δ...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Pharmacological activation of PPARβ/δ...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Espèces réactives de l'oxygène › Pharmacological activation of PPARβ/δ...
questionsmedicales.fr › Techniques d'investigation › Perfusion › Reperfusion › Pharmacological activation of PPARβ/δ...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques respiratoires › Respiration › Pharmacological activation of PPARβ/δ...