Fine-tuning the encapsulation of a photosensitizer in nanoparticles reveals the relationship between internal structure and phototherapeutic effects.
microfluidic device
mitochondria
nanocarrier
photodynamic therapy
Journal
Journal of biophotonics
ISSN: 1864-0648
Titre abrégé: J Biophotonics
Pays: Germany
ID NLM: 101318567
Informations de publication
Date de publication:
03 2023
03 2023
Historique:
revised:
07
07
2022
received:
19
04
2022
accepted:
27
08
2022
pubmed:
3
9
2022
medline:
15
3
2023
entrez:
2
9
2022
Statut:
ppublish
Résumé
Photodynamic therapy (PDT) is a cancer therapy that uses a photosensitizer (PS) in the presence of oxygen molecules. Since singlet oxygen is highly reactive, it is important to deliver it to the target site. Thus, an efficient drug delivery system (DDS) is essential for enhancing the efficacy of such a treatment and protecting against the side effects of PDT. Here, we report on attempts to increase the therapeutic effect of PDT by using a DDS, a lipid nanoparticle (LNP). We prepared a porphyrin analog, rTPA (PS) that was encapsulated in LNPs using a microfluidic device. The findings indicated that the internal structure of the prepared particles changed depending on the amount of rTPA in LNPs. The photoactivity and cell-killing effect of PS in LNPs also changed when the amount of the cargo increased. These results suggest that the internal structure of LNPs is important factors that affect drug efficacy.
Identifiants
pubmed: 36054273
doi: 10.1002/jbio.202200119
doi:
Substances chimiques
Photosensitizing Agents
0
Singlet Oxygen
17778-80-2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e202200119Subventions
Organisme : Grant-in-Aids for Scientific Research
ID : 20H04523
Organisme : Grant-in-Aids for Scientific Research
ID : 21H0175301
Organisme : Scientific Research on Innovative Area
ID : 21K19036
Organisme : Special Education and Research Expenses of the MEXT
ID : JPMJPR19K8
Informations de copyright
© 2022 The Authors. Journal of Biophotonics published by Wiley-VCH GmbH.
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