Oral health status of adult hypophosphatasia patients: A cross-sectional study.
dental status
hypophosphatasia
inflammation
periodontal disease
tooth loss
Journal
Journal of clinical periodontology
ISSN: 1600-051X
Titre abrégé: J Clin Periodontol
Pays: United States
ID NLM: 0425123
Informations de publication
Date de publication:
12 2022
12 2022
Historique:
revised:
03
08
2022
received:
13
04
2022
accepted:
12
08
2022
pubmed:
3
9
2022
medline:
15
11
2022
entrez:
2
9
2022
Statut:
ppublish
Résumé
This study evaluated the oral health status of adult patients with hypophosphatasia (HPP). Parameters of oral health assessment comprised decayed/missing/filled teeth (DMFT) index, probing pocket depth and clinical attachment level (CAL) as well as documentation of tooth loss and periodontal health status according to CCD/AAP criteria. Findings were compared with national reference data (DMS V survey) reporting oral health status in age-related controls. Within-group comparisons were made between the HPP patients harbouring one versus two alkaline phosphatase liver/bone/kidney type (ALPL) gene variants. Of 80 HPP patients (64 female) with a mean age of 46.4 years (range 24-78) and one (n = 55) or two (n = 18) variants (n = 7 lacking testing) within the ALPL gene, those with two variants displayed substantially higher tooth loss rate (14.0 ± 9.3) than those affected by only one ALPL variant (4.1 ± 5.4), who did not differ substantially from healthy DMS V controls. While DMFT score and severe periodontal diseases (PDs) of HPP patients with one variant only increased with progressing age, the two-variant sub-cohort age independently exhibited increased DMFT scores and a higher rate of severe PDs. HPP patients affected by two variants of the ALPL gene exhibited a higher risk of periodontitis and tooth loss than the general population, while patients with one variant developed clinically relevant oral disease symptoms with progressing ageing. gov identifier: NCT02291497.
Substances chimiques
Alkaline Phosphatase
EC 3.1.3.1
Banques de données
ClinicalTrials.gov
['NCT02291497']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1253-1261Subventions
Organisme : Alexion Pharmaceuticals
Informations de copyright
© 2022 The Authors. Journal of Clinical Periodontology published by John Wiley & Sons Ltd.
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