Downregulation of Elovl5 promotes breast cancer metastasis through a lipid-droplet accumulation-mediated induction of TGF-β receptors.
Animals
Breast Neoplasms
/ pathology
Cell Line, Tumor
Down-Regulation
/ genetics
Epithelial-Mesenchymal Transition
Fatty Acid Elongases
/ metabolism
Female
Humans
Lipids
Lung Neoplasms
/ genetics
Mice
Neoplasm Metastasis
Receptors, Transforming Growth Factor beta
/ metabolism
Transforming Growth Factor beta
/ metabolism
Journal
Cell death & disease
ISSN: 2041-4889
Titre abrégé: Cell Death Dis
Pays: England
ID NLM: 101524092
Informations de publication
Date de publication:
02 09 2022
02 09 2022
Historique:
received:
10
03
2022
accepted:
23
08
2022
revised:
19
08
2022
entrez:
2
9
2022
pubmed:
3
9
2022
medline:
9
9
2022
Statut:
epublish
Résumé
Metastatic breast cancer cannot be cured, and alteration of fatty acid metabolism contributes to tumor progression and metastasis. Here, we were interested in the elongation of very long-chain fatty acids protein 5 (Elovl5) in breast cancer. We observed that breast cancer tumors had a lower expression of Elovl5 than normal breast tissues. Furthermore, low expression of Elovl5 is associated with a worse prognosis in ER
Identifiants
pubmed: 36056008
doi: 10.1038/s41419-022-05209-6
pii: 10.1038/s41419-022-05209-6
pmc: PMC9440092
doi:
Substances chimiques
ELOVL5 protein, human
0
Lipids
0
Receptors, Transforming Growth Factor beta
0
Transforming Growth Factor beta
0
Elovl5 protein, mouse
EC 2.3.1.-
Fatty Acid Elongases
EC 2.3.1.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
758Informations de copyright
© 2022. The Author(s).
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