Systemic inflammation enhances stimulant-induced striatal dopamine elevation in tobacco smokers.
Cigarette smoking
Dopamine elevation
Endotoxin
Lipopolysaccharide
Positron emission tomography
Journal
Brain, behavior, and immunity
ISSN: 1090-2139
Titre abrégé: Brain Behav Immun
Pays: Netherlands
ID NLM: 8800478
Informations de publication
Date de publication:
11 2022
11 2022
Historique:
received:
21
03
2022
revised:
25
08
2022
accepted:
29
08
2022
pubmed:
5
9
2022
medline:
14
10
2022
entrez:
4
9
2022
Statut:
ppublish
Résumé
Immune-brain interactions influence the pathophysiology of addiction. Lipopolysaccharide (LPS)-induced systemic inflammation produces effects on reward-related brain regions and the dopamine system. We previously showed that LPS amplifies dopamine elevation induced by methylphenidate (MP), compared to placebo (PBO), in eight healthy controls. However, the effects of LPS on the dopamine system of tobacco smokers have not been explored. The goal of Study 1 was to replicate previous findings in an independent cohort of tobacco smokers. The goal of Study 2 was to combine tobacco smokers with the aforementioned eight healthy controls to examine the effect of LPS on dopamine elevation in a heterogenous sample for power and effect size determination. Eight smokers were each scanned with [
Identifiants
pubmed: 36058419
pii: S0889-1591(22)00372-5
doi: 10.1016/j.bbi.2022.08.016
pmc: PMC10097458
mid: NIHMS1888802
pii:
doi:
Substances chimiques
Central Nervous System Stimulants
0
Lipopolysaccharides
0
Methylphenidate
207ZZ9QZ49
Raclopride
430K3SOZ7G
Dopamine
VTD58H1Z2X
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
262-269Subventions
Organisme : NIA NIH HHS
ID : R21 AG043702
Pays : United States
Organisme : NIAAA NIH HHS
ID : U54 AA027989
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA045465
Pays : United States
Organisme : NIAAA NIH HHS
ID : K01 AA029706
Pays : United States
Organisme : NCATS NIH HHS
ID : KL2 TR001862
Pays : United States
Informations de copyright
Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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