The cAMP/PKA/CREB and TGFβ/SMAD4 Pathways Regulate Stemness and Metastatic Potential in Colorectal Cancer Cells.

Humans Cell Line Colorectal Neoplasms / genetics Cyclic AMP Response Element-Binding Protein / genetics Cyclic AMP-Dependent Protein Kinases / genetics Signal Transduction Smad4 Protein / genetics Transforming Growth Factor beta / genetics Neoplastic Stem Cells / metabolism Neoplasm Metastasis / genetics

Journal

Cancer research
ISSN: 1538-7445
Titre abrégé: Cancer Res
Pays: United States
ID NLM: 2984705R

Informations de publication

Date de publication:
15 11 2022
Historique:
received: 24 04 2022
revised: 28 07 2022
accepted: 30 08 2022
pubmed: 7 9 2022
medline: 18 11 2022
entrez: 6 9 2022
Statut: ppublish

Résumé

This study identifies signaling pathways essential for maintaining the stemness and metastatic potential of colorectal cancer cells and proposes CREB as a therapeutic target in metastatic colorectal cancer.

Identifiants

DOI: 10.1158/0008-5472.CAN-22-1369 PMID: 36066360
pubmed: 36066360
pii: 708953
doi: 10.1158/0008-5472.CAN-22-1369
doi:

Substances chimiques

Cyclic AMP Response Element-Binding Protein 0
Cyclic AMP-Dependent Protein Kinases EC 2.7.11.11
Smad4 Protein 0
SMAD4 protein, human 0
Transforming Growth Factor beta 0
CREB1 protein, human 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

4179-4190

Informations de copyright

©2022 American Association for Cancer Research.

Auteurs

Teruaki Fujishita (T)

Division of Pathophysiology, Aichi Cancer Center Research Institute, Nagoya, Aichi, Japan.
ORCID: 0000-0002-4397-2438

Yasushi Kojima (Y)

Division of Pathophysiology, Aichi Cancer Center Research Institute, Nagoya, Aichi, Japan.
ORCID: 0000-0002-0087-1768

Rie Kajino-Sakamoto (R)

Division of Pathophysiology, Aichi Cancer Center Research Institute, Nagoya, Aichi, Japan.
ORCID: 0000-0001-8194-2515

Emi Mishiro-Sato (E)

Division of Pathophysiology, Aichi Cancer Center Research Institute, Nagoya, Aichi, Japan.
ORCID: 0000-0001-5528-4440

Yasuhiro Shimizu (Y)

Department of Gastroenterological Surgery, Aichi Cancer Center Hospital, Nagoya, Aichi, Japan.
ORCID: 0000-0002-2003-6110

Waki Hosoda (W)

Department of Pathology and Molecular Diagnostics, Aichi Cancer Center Hospital, Nagoya, Aichi, Japan.
ORCID: 0000-0002-9716-7194

Rui Yamaguchi (R)

Division of Cancer Systems Biology, Aichi Cancer Center Research Institute, Nagoya, Aichi, Japan.
Department of Cancer Informatics, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.
ORCID: 0000-0003-1224-227X

Makoto Mark Taketo (MM)

Colon Cancer Project, Kyoto University Hospital-iACT, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto, Japan.
ORCID: 0000-0002-9032-4505

Masahiro Aoki (M)

Division of Pathophysiology, Aichi Cancer Center Research Institute, Nagoya, Aichi, Japan.
Department of Cancer Physiology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.
ORCID: 0000-0003-4316-9490

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The cAMP/PKA/CREB and TGFβ/SMAD4 Pathways...
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › The cAMP/PKA/CREB and TGFβ/SMAD4 Pathways...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Maladies du rectum › Tumeurs colorectales › The cAMP/PKA/CREB and TGFβ/SMAD4 Pathways...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif basique et à glissière à leucines › Protéine de liaison à l'élément de réponse à l'AMP cyclique › The cAMP/PKA/CREB and TGFβ/SMAD4 Pathways...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Cyclic Nucleotide-Regulated Protein Kinases › Cyclic AMP-Dependent Protein Kinases › The cAMP/PKA/CREB and TGFβ/SMAD4 Pathways...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › The cAMP/PKA/CREB and TGFβ/SMAD4 Pathways...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Protéines Smad › Protéine Smad-4 › The cAMP/PKA/CREB and TGFβ/SMAD4 Pathways...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Protéines de la superfamille du TGF bêta › Facteur de croissance transformant bêta › The cAMP/PKA/CREB and TGFβ/SMAD4 Pathways...
questionsmedicales.fr › Cellules › Cellules souches › Cellules souches tumorales › The cAMP/PKA/CREB and TGFβ/SMAD4 Pathways...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Processus néoplasiques › Métastase tumorale › The cAMP/PKA/CREB and TGFβ/SMAD4 Pathways...