Triple helix and rod structures of the antiseptic drug bibrocathol revealed by electron crystallography.

Anti-Infective Agents, Local / pharmacology Catechols Crystallography / methods Crystallography, X-Ray Electrons Ointments

Journal

Chemical communications (Cambridge, England)
ISSN: 1364-548X
Titre abrégé: Chem Commun (Camb)
Pays: England
ID NLM: 9610838

Informations de publication

Date de publication:
22 Sep 2022
Historique:
pubmed: 8 9 2022
medline: 28 9 2022
entrez: 7 9 2022
Statut: epublish

Résumé

Bibrocathol is an active pharmaceutical ingredient that has been used to treat eyelid diseases for over a century, yet its structure has remained unknown. 3D electron diffraction on crystals from a commercial ointment revealed two structures. These results highlight the technique's potential in structure elucidation from microcrystalline mixtures.

Identifiants

DOI: 10.1039/d2cc04209f PMID: 36069049
pubmed: 36069049
doi: 10.1039/d2cc04209f
doi:

Substances chimiques

Anti-Infective Agents, Local 0
Catechols 0
Ointments 0
bibrocathol 0KJ20H1BLJ

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

10695-10698

Auteurs

Erik Svensson Grape (E)

Department of Materials and Environmental Chemistry, Stockholm University, SE-106 91, Stockholm, Sweden. erik.grape@mmk.su.se.
ORCID: 0000-0002-8956-5897

Tom Willhammar (T)

Department of Materials and Environmental Chemistry, Stockholm University, SE-106 91, Stockholm, Sweden. erik.grape@mmk.su.se.
ORCID: 0000-0001-6120-1218

A Ken Inge (AK)

Department of Materials and Environmental Chemistry, Stockholm University, SE-106 91, Stockholm, Sweden. erik.grape@mmk.su.se.
ORCID: 0000-0001-9118-1342

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Anti-infectieux locaux › Triple helix and rod structures of the...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Phénols › Catéchols › Triple helix and rod structures of the...
questionsmedicales.fr › Disciplines des sciences naturelles › Chimie › Chimie physique › Cristallographie › Triple helix and rod structures of the...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Cristallographie aux rayons X › Triple helix and rod structures of the...
questionsmedicales.fr › Phénomènes physiques › Phénomènes magnétiques › Phénomènes électromagnétiques › Électrons › Triple helix and rod structures of the...
questionsmedicales.fr › Préparations pharmaceutiques › Onguents › Triple helix and rod structures of the...