Inter- and Intraindividual Differences in the Capacity of the Human Intestinal Microbiome in Fecal Slurries to Metabolize Fructoselysine and Carboxymethyllysine.
16S rRNA analysis
advanced glycation end product
human gut microbiota
interindividual differences
intraindividual differences
new approach methodologies
temporal variability
Journal
Journal of agricultural and food chemistry
ISSN: 1520-5118
Titre abrégé: J Agric Food Chem
Pays: United States
ID NLM: 0374755
Informations de publication
Date de publication:
21 Sep 2022
21 Sep 2022
Historique:
pubmed:
8
9
2022
medline:
24
9
2022
entrez:
7
9
2022
Statut:
ppublish
Résumé
The advanced glycation endproduct carboxymethyllysine and its precursor fructoselysine are present in heated, processed food products and are considered potentially hazardous for human health. Upon dietary exposure, they can be degraded by human colonic gut microbiota, reducing internal exposure. Pronounced interindividual and intraindividual differences in these metabolic degradations were found in anaerobic incubations with human fecal slurries in vitro. The average capacity to degrade fructoselysine was 27.7-fold higher than that for carboxymethyllysine, and degradation capacities for these two compounds were not correlated (
Identifiants
pubmed: 36069406
doi: 10.1021/acs.jafc.2c05756
pmc: PMC9501902
doi:
Substances chimiques
Glycation End Products, Advanced
0
RNA, Ribosomal, 16S
0
fructosyl-lysine
21291-40-7
N(6)-carboxymethyllysine
70YDX3Z2O7
Lysine
K3Z4F929H6
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
11759-11768Références
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