The impact of COVID-19 vaccination on glycaemic control in children and adolescents with type 1 diabetes mellitus on continuous glucose monitoring.
Adolescents
COVID-19
Children
SARS-Cov-2
Type 1 diabetes mellitus
Vaccination
Journal
Acta diabetologica
ISSN: 1432-5233
Titre abrégé: Acta Diabetol
Pays: Germany
ID NLM: 9200299
Informations de publication
Date de publication:
Dec 2022
Dec 2022
Historique:
received:
19
07
2022
accepted:
29
08
2022
pubmed:
8
9
2022
medline:
22
10
2022
entrez:
7
9
2022
Statut:
ppublish
Résumé
To investigate the impact of SARS-COV-2 vaccination on the glycaemic control in children and adolescents with T1DM wearing continuous glucose monitoring (CGM). Caregivers of children and adolescents with T1DM were questioned regarding SARS-CoV-2 vaccination during their regular visits at the Pediatric Diabetes Outpatient Clinic. Data regarding Time in Range (TIR) (glucose levels: 70-180 mg/dl) 7 days prior and 7 days after a vaccination dose were collected in patients wearing CGM and data regarding insulin daily doses were also obtained for the insulin pump users. From a total of 135 patients eligible for SARS-CoV-2 vaccination, 70 (51.9%) children (37 boys, 52.9%) were vaccinated with at least one dose. Seven patients received only one dose, whereas two children received a third booster shot. No statistically significant difference was observed in either TIR (64.19% post vs. 65.53% pre, p = 0.158) or total daily insulin dose (40.08 U/day post vs. 39.32 U/day pre, p = 0,282). Additionally, in ten patients on Hybrid Closed-Loop System the percentage of the automated insulin boluses given post-vaccination was not statistically significant different compared to the boluses given pre-vaccination (15.80% vs. 16.90%, p = 0,491). Vaccination against SARS-CoV-2 in children and adolescents with T1DM is safe and is not associated with immediate glucose imbalance.
Identifiants
pubmed: 36069940
doi: 10.1007/s00592-022-01968-y
pii: 10.1007/s00592-022-01968-y
pmc: PMC9449273
doi:
Substances chimiques
COVID-19 Vaccines
0
Blood Glucose
0
Hypoglycemic Agents
0
Insulin
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1609-1614Informations de copyright
© 2022. The Author(s).
Références
(2020) WHO announces COVID-19 outbreak a pandemic. https://www.euro.who.int/en/health-topics/health-emergencies/coronavirus-covid-19/news/news/2020/3/who-announces-covid-19-outbreak-a-pandemic . Accessed 16 Apr 2022
Erener S (2020) Diabetes, infection risk and COVID-19. Mol Metab. https://doi.org/10.1016/J.MOLMET.2020.101044
doi: 10.1016/J.MOLMET.2020.101044
pubmed: 32585364
pmcid: 7308743
Dimeglio LA, Albanese-O’neill A, Muñoz CE et al (2020) COVID-19 and children with diabetes-updates, unknowns, and next steps: first, do no extrapolation. Diabetes Care 43:2631–2634. https://doi.org/10.2337/DCI20-0044
doi: 10.2337/DCI20-0044
pubmed: 32887703
Troiano G, Nardi A (2021) Vaccine hesitancy in the era of COVID-19. Public Health 194:245–251. https://doi.org/10.1016/J.PUHE.2021.02.025
doi: 10.1016/J.PUHE.2021.02.025
pubmed: 33965796
Children and COVID-19 Vaccination Trends. https://www.aap.org/en/pages/2019-novel-coronavirus-covid-19-infections/children-and-covid-19-vaccination-trends/ . Accessed 16 Apr 2022
Scaramuzza AE, Cherubini V, Schiaffini R et al (2022) A nationwide survey of Italian pediatric diabetologists about COVID-19 vaccination in children and adolescents with type 1 diabetes. Acta Diabetol. https://doi.org/10.1007/S00592-022-01885-0
doi: 10.1007/S00592-022-01885-0
pubmed: 35449238
pmcid: 9022735
Ganakumar V, Jethwani P, Roy A et al (2022) Diabetic ketoacidosis (DKA) in type 1 diabetes mellitus (T1DM) temporally related to COVID-19 vaccination. Diabetes Metab Syndr. https://doi.org/10.1016/J.DSX.2021.102371
doi: 10.1016/J.DSX.2021.102371
pubmed: 34954484
Samuel SM, Varghese E, Triggle CR, Büsselberg D (2022) COVID-19 vaccines and hyperglycemia—is there a need for postvaccination surveillance? Vaccines (Basel) 10:454. https://doi.org/10.3390/VACCINES10030454
doi: 10.3390/VACCINES10030454
Aberer F, Moser O, Aziz F et al (2022) Impact of COVID-19 vaccination on glycemia in individuals with type 1 and type 2 diabetes: substudy of the COVAC-DM study. Diabetes Care 45:e24–e26. https://doi.org/10.2337/DC21-1563
doi: 10.2337/DC21-1563
pubmed: 34848490
Heald AH, Stedman M, Horne L et al (2022) The change in glycaemic control immediately after COVID-19 vaccination in people with type 1 diabetes. Diabet Med. https://doi.org/10.1111/DME.14774
doi: 10.1111/DME.14774
pubmed: 34936128
Heald AH, Rea R, Horne L et al (2021) Analysis of continuous glucose tracking data in people with type 1 diabetes after COVID-19 vaccination reveals unexpected link between immune and metabolic response, augmented by adjunctive oral medication. Int J Clin Pract. https://doi.org/10.1111/IJCP.14714
doi: 10.1111/IJCP.14714
pubmed: 34626513
Principi N, Esposito S (2022) Reasons in favour of universal vaccination campaign against COVID-19 in the pediatric population. Ital J Pediatr. https://doi.org/10.1186/S13052-021-01192-4
doi: 10.1186/S13052-021-01192-4
pubmed: 35986340
pmcid: 9389475
Kabeerdoss J, Pilania RK, Karkhele R et al (2021) Severe COVID-19, multisystem inflammatory syndrome in children, and Kawasaki disease: immunological mechanisms, clinical manifestations and management. Rheumatol Int 41:19–32. https://doi.org/10.1007/S00296-020-04749-4
doi: 10.1007/S00296-020-04749-4
pubmed: 33219837
Sourij C, Tripolt NJ, Aziz F et al (2022) Humoral immune response to COVID-19 vaccination in diabetes is age-dependent but independent of type of diabetes and glycaemic control: the prospective COVAC-DM cohort study. Diabetes Obes Metab. https://doi.org/10.1111/DOM.14643
doi: 10.1111/DOM.14643
pubmed: 36057945
pmcid: 9538806
Scoccimarro D, Panichi L, Ragghianti B et al (2021) Sars-CoV2 vaccine hesitancy in Italy: a survey on subjects with diabetes. Nutr Metab Cardiovasc Dis 31:3243–3246. https://doi.org/10.1016/J.NUMECD.2021.09.002
doi: 10.1016/J.NUMECD.2021.09.002
pubmed: 34629250
pmcid: 8428984