Tranexamic acid for safer surgery: the time is now.

Blood Loss, Surgical / prevention & control Clinical Trials as Topic Humans Tranexamic Acid / therapeutic use
bleeding clinical trial surgery thromboembolic events tranexamic acid

Journal

British journal of anaesthesia
ISSN: 1471-6771
Titre abrégé: Br J Anaesth
Pays: England
ID NLM: 0372541

Informations de publication

Date de publication:
10 2022
Historique:
received: 14 06 2022
revised: 22 06 2022
accepted: 24 06 2022
pubmed: 8 9 2022
medline: 6 10 2022
entrez: 7 9 2022
Statut: ppublish

Résumé

Tranexamic acid reduces surgical bleeding. Consistent with previous research, the POISE-3 (Peri-Operative Ischemic Evaluation-3) trial found that tranexamic acid reduces major bleeding by 25% and with a low probability of any increase in thromboembolic events. Wider tranexamic acid use will improve surgical safety, avoid unnecessary blood use, reduce the risk of transfusion transmitted infections, and save healthcare funds. 'Consideration of tranexamic acid use' should be included in the safe surgery checklist. We have the evidence, and we need to act on it.

Identifiants

DOI: 10.1016/j.bja.2022.06.024 PMID: 36070986
pubmed: 36070986
pii: S0007-0912(22)00344-0
doi: 10.1016/j.bja.2022.06.024
pii:
doi:

Substances chimiques

Tranexamic Acid 6T84R30KC1

Types de publication

Editorial

Langues

eng

Sous-ensembles de citation

IM

Pagination

459-461

Subventions

Organisme : Medical Research Council
ID : MR/M009211/1
Pays : United Kingdom

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2022 The Author(s). Published by Elsevier Ltd.. All rights reserved.

Auteurs

Michael P W Grocott (MPW)

Royal College of Anaesthetists, London, UK; NIHR Southampton Biomedical Research Centre, University Hospital Southampton/University of Southampton, Southampton, UK.

Mike Murphy (M)

NHS Blood and Transplant, Oxford University Hospitals NHS Foundation Trust and the University of Oxford, Oxford, UK.

Ian Roberts (I)

Clinical Trials Unit, London School of Hygiene and Tropical Medicine, London, UK. Electronic address: Ian.Roberts@lshtm.ac.uk.

Rob Sayers (R)

University of Leicester, Leicester, UK; Royal College of Surgeons of England, London, UK.

Cheng-Hock Toh (CH)

University of Liverpool, Liverpool, UK; Royal College of Physicians, London, UK.

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Classifications MeSH

questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Complications peropératoires › Perte sanguine peropératoire › Tranexamic acid for safer surgery: the time is now.
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études cliniques comme sujet › Essais cliniques comme sujet › Tranexamic acid for safer surgery: the time is now.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Tranexamic acid for safer surgery: the time is now.
questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Acides carbocycliques › Acide tranéxamique › Tranexamic acid for safer surgery: the time is now.