Mechanistic Insights into Angiotensin I-Converting Enzyme Inhibitory Tripeptides to Decipher the Chemical Basis of Their Activity.

angiotensin I-converting enzyme antihypertensive peptides bioactive peptides structure−activity relationship

Journal

Journal of agricultural and food chemistry
ISSN: 1520-5118
Titre abrégé: J Agric Food Chem
Pays: United States
ID NLM: 0374755

Informations de publication

Date de publication:
21 Sep 2022
Historique:
pubmed: 9 9 2022
medline: 24 9 2022
entrez: 8 9 2022
Statut: ppublish

Résumé

Food proteins are an important source of bioactive peptides, and the angiotensin I-converting enzyme (ACE) inhibitors are worthy of attention for their possible beneficial effects in subjects with mild hypertension. However, the chemical basis underpinning their activity is not well-understood, hampering the discovery of novel inhibitory sequences from the plethora of peptides encrypted in food proteins. This work combined computational and

Identifiants

pubmed: 36074807
doi: 10.1021/acs.jafc.2c04755
pmc: PMC9501895
doi:

Substances chimiques

Angiotensin-Converting Enzyme Inhibitors 0
Peptides 0
Peptidyl-Dipeptidase A EC 3.4.15.1

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

11572-11578

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Auteurs

Carmen Lammi (C)

Department of Pharmaceutical Sciences, University of Milan, Via Mangiagalli 25, Milan 20133, Italy.

Giovanna Boschin (G)

Department of Pharmaceutical Sciences, University of Milan, Via Mangiagalli 25, Milan 20133, Italy.

Martina Bartolomei (M)

Department of Pharmaceutical Sciences, University of Milan, Via Mangiagalli 25, Milan 20133, Italy.

Anna Arnoldi (A)

Department of Pharmaceutical Sciences, University of Milan, Via Mangiagalli 25, Milan 20133, Italy.

Gianni Galaverna (G)

Department of Food and Drug, University of Parma, Parco Area delle Scienze 27/A, Parma 43124, Italy.

Luca Dellafiora (L)

Department of Food and Drug, University of Parma, Parco Area delle Scienze 27/A, Parma 43124, Italy.

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Classifications MeSH