Histone Deacetylases Cooperate with NF-κB to Support the Immediate Migratory Response after Zebrafish Pronephros Injury.
HDAC
acute kidney injury
directed cell migration
epigenetic modifiers
histone deacetylase
laser ablation
zebrafish pronephros
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
24 Aug 2022
24 Aug 2022
Historique:
received:
05
08
2022
revised:
19
08
2022
accepted:
20
08
2022
entrez:
9
9
2022
pubmed:
10
9
2022
medline:
14
9
2022
Statut:
epublish
Résumé
Acute kidney injury (AKI) is commonly associated with severe human diseases, and often worsens the outcome in hospitalized patients. The mammalian kidney has the ability to recover spontaneously from AKI; however, little progress has been made in the development of supportive treatments. Increasing evidence suggest that histone deacetylases (HDAC) and NF-κB promote the pathogenesis of AKI, and inhibition of Hdac activity has a protective effect in murine models of AKI. However, the role of HDAC at the early stages of recovery is unknown. We used the zebrafish pronephros model to study the role of epigenetic modifiers in the immediate repair response after injury to the tubular epithelium. Using specific inhibitors, we found that the histone deacetylase Hdac2, Hdac6, and Hdac8 activities are required for the repair via collective cell migration. We found that
Identifiants
pubmed: 36076983
pii: ijms23179582
doi: 10.3390/ijms23179582
pmc: PMC9455417
pii:
doi:
Substances chimiques
HDAC8 protein, zebrafish
0
Histone Deacetylase Inhibitors
0
NF-kappa B
0
Repressor Proteins
0
Zebrafish Proteins
0
HDAC6 protein, zebrafish
EC 3.5.1.98
Histone Deacetylase 6
EC 3.5.1.98
Histone Deacetylases
EC 3.5.1.98
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : Project-ID 431984000 - SFB 1453
Organisme : Deutsche Forschungsgemeinschaft
ID : CIBSS_EXC-Project ID 390939984
Organisme : Else-Kröner Fresenius Stiftung
ID : to G.W.
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