Dock10 Regulates Cardiac Function under Neurohormonal Stress.


Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
25 Aug 2022
Historique:
received: 11 07 2022
revised: 22 08 2022
accepted: 23 08 2022
entrez: 9 9 2022
pubmed: 10 9 2022
medline: 14 9 2022
Statut: epublish

Résumé

Dedicator of cytokinesis 10 (Dock10) is a guanine nucleotide exchange factor for Cdc42 and Rac1 that regulates the JNK (c-Jun N-terminal kinase) and p38 MAPK (mitogen-activated protein kinase) signaling cascades. In this study, we characterized the roles of Dock10 in the myocardium. In vitro: we ablated Dock10 in neonatal mouse floxed

Identifiants

pubmed: 36077014
pii: ijms23179616
doi: 10.3390/ijms23179616
pmc: PMC9455810
pii:
doi:

Substances chimiques

DOCK10 protein, mouse 0
Guanine Nucleotide Exchange Factors 0
Angiotensin II 11128-99-7
JNK Mitogen-Activated Protein Kinases EC 2.7.11.24
p38 Mitogen-Activated Protein Kinases EC 2.7.11.24

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : National Institute for Biotechnology in the Negev
ID : No Number
Organisme : NEI NIH HHS
ID : P30 EY026877
Pays : United States
Organisme : Gassner Fund for Medical Research
ID : No Number
Organisme : National Institute of Health
ID : R01HL158052
Organisme : NHLBI NIH HHS
ID : R01 HL158052
Pays : United States

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Auteurs

Liad Segal (L)

Department of Physiology and Cell Biology, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.
Regenerative Medicine and Stem Cell (RMSC) Research Center, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.

Sharon Etzion (S)

Regenerative Medicine and Stem Cell (RMSC) Research Center, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.

Sigal Elyagon (S)

Department of Physiology and Cell Biology, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.
Regenerative Medicine and Stem Cell (RMSC) Research Center, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.

Moran Shahar (M)

Department of Physiology and Cell Biology, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.

Hadar Klapper-Goldstein (H)

Department of Physiology and Cell Biology, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.
Regenerative Medicine and Stem Cell (RMSC) Research Center, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.

Aviva Levitas (A)

Pediatric Cardiology Department, Soroka University Medical Center, Beer-Sheva 8410501, Israel.

Michael S Kapiloff (MS)

Departments of Ophthalmology and Medicine (Cardiovascular Medicine), Stanford Cardiovascular Institute, Stanford University, Palo Alto 94304-1209, CA, USA.

Ruti Parvari (R)

The Shraga Segal Department of Microbiology, Immunology and Genetics, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.
National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.

Yoram Etzion (Y)

Department of Physiology and Cell Biology, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.
Regenerative Medicine and Stem Cell (RMSC) Research Center, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.

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Classifications MeSH