Quantitative Phosphoproteomics of the Angiotensin AT

Humans Tumor Suppressor Protein p53 / metabolism Histones Receptor, Angiotensin, Type 2 / metabolism Endothelial Cells / metabolism Apoptosis Phosphoric Monoester Hydrolases / metabolism Serine Angiotensins / metabolism Histone Deacetylase 1 / metabolism
angiotensin receptors apoptosis endothelial cells histone deacetylase 1 phosphoproteomics

Journal

Hypertension (Dallas, Tex. : 1979)
ISSN: 1524-4563
Titre abrégé: Hypertension
Pays: United States
ID NLM: 7906255

Informations de publication

Date de publication:
11 2022
Historique:
pubmed: 10 9 2022
medline: 19 11 2022
entrez: 9 9 2022
Statut: ppublish

Résumé

Angiotensin AT Phosphorylation status of human aortic endothelial cells after stimulation with C21 (1 µM; 0, 1, 3, 5, 20 minutes) was determined utilizing time-resolved quantitative phosphoproteomics. Specific changes in protein phosphorylation and acetylation were confirmed by Western Blotting. Functional tests included resazurin assay for cell proliferation, and caspase 3/7 luminescence assay or FACS analysis of annexin V expression for apoptosis. AT Contrary to the prevailing view that AT

Sections du résumé

BACKGROUND
Angiotensin AT
METHODS
Phosphorylation status of human aortic endothelial cells after stimulation with C21 (1 µM; 0, 1, 3, 5, 20 minutes) was determined utilizing time-resolved quantitative phosphoproteomics. Specific changes in protein phosphorylation and acetylation were confirmed by Western Blotting. Functional tests included resazurin assay for cell proliferation, and caspase 3/7 luminescence assay or FACS analysis of annexin V expression for apoptosis.
RESULTS
AT
CONCLUSIONS
Contrary to the prevailing view that AT

Identifiants

DOI: 10.1161/HYPERTENSIONAHA.121.18620 PMID: 36082664
pubmed: 36082664
doi: 10.1161/HYPERTENSIONAHA.121.18620
doi:

Substances chimiques

compound 21 RC2V4W0EYC
Tumor Suppressor Protein p53 0
Histones 0
Receptor, Angiotensin, Type 2 0
Phosphoric Monoester Hydrolases EC 3.1.3.2
Serine 452VLY9402
Angiotensins 0
HDAC1 protein, human EC 3.5.1.98
Histone Deacetylase 1 EC 3.5.1.98

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2530-2541

Auteurs

A Augusto Peluso (AA)

IMM - Department of Cardiovascular and Renal Research (A.A.P., G.K., A.H.H., U.M.S.), University of Southern Denmark, Odense.
Now with Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark (A.A.P.).
ORCID: 0000-0002-8653-2248

Stefan J Kempf (SJ)

Department of Biochemistry and Molecular Biology (S.J.K., M.R.L.), University of Southern Denmark, Odense.
Now with CSL Behring, Department of Bioanalytical Sciences, Marburg, Germany (S.J.K.).

Thiago Verano-Braga (T)

National Institute of Science and Technology in Nanobiopharmaceutics, Department of Physiology and Biophysics, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil (T.V.-B., L.R.-R., R.A.S.).
ORCID: 0000-0002-7083-2588

Lucas Rodrigues-Ribeiro (L)

National Institute of Science and Technology in Nanobiopharmaceutics, Department of Physiology and Biophysics, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil (T.V.-B., L.R.-R., R.A.S.).
ORCID: 0000-0002-4011-637X

Lene Egedal Johansen (LE)

IMM - Department of Cancer and Inflammation Research (L.E.J., H.J.D.), University of Southern Denmark, Odense.

Mie Rytz Hansen (MR)

Gitte Kitlen (G)

IMM - Department of Cardiovascular and Renal Research (A.A.P., G.K., A.H.H., U.M.S.), University of Southern Denmark, Odense.

Andreas Houe Haugaard (AH)

IMM - Department of Cardiovascular and Renal Research (A.A.P., G.K., A.H.H., U.M.S.), University of Southern Denmark, Odense.

Colin Sumners (C)

Department of Physiology and Functional Genomics, University of Florida, Gainesville (C.S.).
ORCID: 0000-0002-9689-2255

Henrik J Ditzel (HJ)

IMM - Department of Cancer and Inflammation Research (L.E.J., H.J.D.), University of Southern Denmark, Odense.
Department of Oncology, Odense University Hospital, Denmark (H.J.D.).
ORCID: 0000-0003-3927-5135

Robson A Santos (RA)

National Institute of Science and Technology in Nanobiopharmaceutics, Department of Physiology and Biophysics, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil (T.V.-B., L.R.-R., R.A.S.).
ORCID: 0000-0001-8738-5852

Michael Bader (M)

Max Delbrück Center for Molecular Medicine, Berlin, Germany (M.B.).
Charite - University Medicine, Berlin, Germany (M.B.).
DZHK, Berlin, Germany (M.B.).
Institute for Biology, University of Lübeck, Germany (M.B.).

Martin R Larsen (MR)

Department of Biochemistry and Molecular Biology (S.J.K., M.R.L.), University of Southern Denmark, Odense.

U Muscha Steckelings (UM)

IMM - Department of Cardiovascular and Renal Research (A.A.P., G.K., A.H.H., U.M.S.), University of Southern Denmark, Odense.
ORCID: 0000-0002-5430-4275

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Quantitative Phosphoproteomics of the Angiotensin AT
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Phosphoprotéines › Protéine p53 suppresseur de tumeur › Quantitative Phosphoproteomics of the Angiotensin AT
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Histone › Quantitative Phosphoproteomics of the Angiotensin AT
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteurs aux angiotensines › Récepteur de type 2 à l'angiotensine-II › Quantitative Phosphoproteomics of the Angiotensin AT
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules endothéliales › Quantitative Phosphoproteomics of the Angiotensin AT
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › Quantitative Phosphoproteomics of the Angiotensin AT
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Phosphoric monoester hydrolases › Quantitative Phosphoproteomics of the Angiotensin AT
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés neutres › Sérine › Quantitative Phosphoproteomics of the Angiotensin AT
questionsmedicales.fr › Facteurs biologiques › Médiateurs de l'inflammation › Autacoïdes › Angiotensines › Quantitative Phosphoproteomics of the Angiotensin AT
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Complexes multienzymatiques › Histone Deacetylase 1 › Quantitative Phosphoproteomics of the Angiotensin AT