Human dental pulp cells modulate CD8
Adenine nucleotides
Adenosine
CD73
CD8(+) T cells
Cell-based immunotherapy
Dental pulp cells
Immunosuppression
Mesenchymal stem cells
Tregs
purinergic signaling
Journal
Cellular immunology
ISSN: 1090-2163
Titre abrégé: Cell Immunol
Pays: Netherlands
ID NLM: 1246405
Informations de publication
Date de publication:
10 2022
10 2022
Historique:
received:
26
04
2022
revised:
27
07
2022
accepted:
10
08
2022
pubmed:
10
9
2022
medline:
16
9
2022
entrez:
9
9
2022
Statut:
ppublish
Résumé
The pulp of human teeth contains a population of self-renewing stem cells that can regulate the functions of immune cells. When applied to patients, these cells can protect tissues from damage by excessive inflammation. We confirm that dental pulp cells effectively inhibit the proliferation and activation of cytotoxic T cells in vitro, and show that they carry high levels of CD73, a key enzyme in the conversion of pro-inflammatory extracellular ATP to immunosuppressive adenosine. Given their accessibility and abundance, as well as their potential for allogeneic administration, dental pulp cells provide a valuable source for immunomodulatory therapy.
Identifiants
pubmed: 36084401
pii: S0008-8749(22)00114-9
doi: 10.1016/j.cellimm.2022.104589
pii:
doi:
Substances chimiques
Adenosine Triphosphate
8L70Q75FXE
5'-Nucleotidase
EC 3.1.3.5
Adenosine
K72T3FS567
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
104589Informations de copyright
Copyright © 2022 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.