Histamine Excretion by the Common Bed Bug (Hemiptera: Cimicidae).
aggregation pheromone
allergen
bed bug
blood-sucking pest
histamine
Journal
Journal of medical entomology
ISSN: 1938-2928
Titre abrégé: J Med Entomol
Pays: England
ID NLM: 0375400
Informations de publication
Date de publication:
16 11 2022
16 11 2022
Historique:
received:
30
06
2022
pubmed:
11
9
2022
medline:
19
11
2022
entrez:
10
9
2022
Statut:
ppublish
Résumé
The common bed bug (Cimex lectularius L.) is a hematophagous pest species that lives in close proximity to humans. Following a blood meal, bed bugs deposit fecal material indoors. The feces contain a variety of compounds, including histamine, which serves as a component of their aggregation pheromone. Histamine is a pivotal mammalian immune modulator, and recently it was shown to be present in high concentrations in household dust from homes infested with bed bugs. To better understand the dynamics of histamine excretion, we analyzed bed bug fecal material from different life stages and populations, along with fecal material collected at different post-feeding times and from bed bugs fed on different diets. Our analysis showed significant variation in histamine excretion among life stages, with mated females excreting the most histamine and first instar nymphs excreting the least histamine. However, when histamine excretion was normalized for blood consumption, males were found to excrete more histamine than the other life stages. There was no difference in histamine excretion among laboratory and recently home-collected bed bug populations. Further, we found histamine excretion continued for at least 14 d post-feeding, with the highest amount of histamine excreted 3-4 d after a bloodmeal. Overall, this work demonstrates that bed bugs excrete histamine across all feeding life stages, populations, and at various times after feeding, and that histamine excretion is directly related to blood feeding. These results will be used to better understand the health risks associated with histamine excretion and potential mitigation strategies of environmental histamine.
Identifiants
pubmed: 36086827
pii: 6695124
doi: 10.1093/jme/tjac131
pmc: PMC9667729
doi:
Substances chimiques
Histamine
820484N8I3
Pheromones
0
Types de publication
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1898-1904Subventions
Organisme : NIH HHS
ID : DP5 OD028155
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES025128
Pays : United States
Organisme : NIH HHS
ID : DP5-OD028155 to ZCD
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30ES025128
Pays : United States
Informations de copyright
© The Author(s) 2022. Published by Oxford University Press on behalf of Entomological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
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