Colorectal Neoplasia in CDH1 Pathogenic Variant Carriers: A Multicenter Analysis.
Journal
The American journal of gastroenterology
ISSN: 1572-0241
Titre abrégé: Am J Gastroenterol
Pays: United States
ID NLM: 0421030
Informations de publication
Date de publication:
01 11 2022
01 11 2022
Historique:
received:
18
04
2022
accepted:
23
08
2022
pubmed:
11
9
2022
medline:
8
11
2022
entrez:
10
9
2022
Statut:
ppublish
Résumé
Germline variants in CDH1 are associated with elevated risks of diffuse gastric cancer and lobular breast cancer. It is uncertain whether there is an increased risk of colorectal neoplasia. This was a retrospective analysis of colonoscopy outcomes in patients with germline CDH1 pathogenic/likely pathogenic variants. Eighty-five patients were included with a mean age of 46.9 years. Initial colonoscopy found adenomatous polyps in 30 patients (35.3%), including advanced adenomas in 9 (10.6%). No colorectal cancers were identified on index or subsequent colonoscopies (when available). CDH1 carriers have colorectal neoplasia identified at similar rates as in the general population. Despite potential difficulties after gastrectomy, colorectal cancer screening remains important in this population.
Identifiants
pubmed: 36087100
doi: 10.14309/ajg.0000000000001996
pii: 00000434-202211000-00031
doi:
Substances chimiques
CDH1 protein, human
0
Antigens, CD
0
Cadherins
0
Types de publication
Multicenter Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1877-1879Subventions
Organisme : NCATS NIH HHS
ID : UL1 TR002733
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA168524
Pays : United States
Informations de copyright
Copyright © 2022 by The American College of Gastroenterology.
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