Central precuneus lesions are associated with impaired executive function.
Brain lesions
Executive dysfunction
Lesion network mapping
Lesion symptom mapping
Trail-making test
Journal
Brain structure & function
ISSN: 1863-2661
Titre abrégé: Brain Struct Funct
Pays: Germany
ID NLM: 101282001
Informations de publication
Date de publication:
Dec 2022
Dec 2022
Historique:
received:
02
06
2022
accepted:
17
08
2022
pubmed:
11
9
2022
medline:
16
11
2022
entrez:
10
9
2022
Statut:
ppublish
Résumé
The functional roles of the precuneus are unclear. Focal precuneus lesions are rare, making it difficult to identify robust brain-behavior relationships. Distinct functional subdivisions of the precuneus have been proposed based on unique connectivity profiles. This includes an association of the anterior division with bodily awareness, the central region with complex cognition, and the posterior division with visual processing. Our goal was to test the hypothesis that the central precuneus is preferentially involved (compared to the other sectors of the precuneus) in executive function, as estimated from performance on the trail-making test (TMT). 35 patients with focal brain lesions involving the precuneus were included from the University of Iowa and Montpellier University. Multivariate lesion symptom mapping of TMT performance was performed to evaluate whether lesion location was associated with impaired task performance. Lesion symptom mapping revealed a statistically significant association of central precuneus lesions with impaired TMT performance (r = 0.43, p < 0.01). Further, a functional network derived from this precuneus region showed connectivity to other cortical areas implicated in executive function, including the dorsolateral prefrontal cortex and inferior parietal lobe. This analysis provides support for the role of the central precuneus in executive function, consistent with the unique connectivity pattern of the central precuneus with a broader network implicated in cognitive control and executive function.
Identifiants
pubmed: 36087124
doi: 10.1007/s00429-022-02556-0
pii: 10.1007/s00429-022-02556-0
pmc: PMC9743014
mid: NIHMS1848020
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3099-3108Subventions
Organisme : NIH HHS
ID : T32-NS007421
Pays : United States
Organisme : NIMH NIH HHS
ID : R21MH120441
Pays : United States
Organisme : NINDS NIH HHS
ID : RO1-NS114405
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS114405
Pays : United States
Organisme : NICHD NIH HHS
ID : P50 HD103556
Pays : United States
Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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