Cyclic Nucleotide Phosphodiesterases in Alcohol Use Disorders: Involving Gut Microbiota.
AUD
Cyclic nucleotide phosphodiesterase
PDE
alcohol use disorder
gut microbiota
Journal
The international journal of neuropsychopharmacology
ISSN: 1469-5111
Titre abrégé: Int J Neuropsychopharmacol
Pays: England
ID NLM: 9815893
Informations de publication
Date de publication:
19 01 2023
19 01 2023
Historique:
received:
27
12
2021
revised:
18
08
2022
accepted:
09
09
2022
pubmed:
11
9
2022
medline:
21
1
2023
entrez:
10
9
2022
Statut:
ppublish
Résumé
Alcohol abuse is 1 of the most significant public health problems in the world. Chronic, excessive alcohol consumption not only causes alcohol use disorder (AUD) but also changes the gut and lung microbiota, including bacterial and nonbacterial types. Both types of microbiota can release toxins, further damaging the gastrointestinal and respiratory tracts; causing inflammation; and impairing the functions of the liver, lung, and brain, which in turn deteriorate AUD. Phosphodiesterases (PDEs) are critical in the control of intracellular cyclic nucleotides, including cyclic adenosine monophosphate and cyclic guanosine monophosphate. Inhibition of certain host PDEs reduces alcohol consumption and attenuates alcohol-related impairment. These PDEs are also expressed in the microbiota and may play a role in controlling microbiota-associated inflammation. Here, we summarize the influences of alcohol on gut/lung bacterial and nonbacterial microbiota as well as on the gut-liver/brain/lung axis. We then discuss the relationship between gut and lung microbiota-mediated PDE signaling and AUD consequences in addition to highlighting PDEs as potential targets for treatment of AUD.
Identifiants
pubmed: 36087271
pii: 6695374
doi: 10.1093/ijnp/pyac060
pmc: PMC9850663
doi:
Substances chimiques
3',5'-Cyclic-AMP Phosphodiesterases
EC 3.1.4.17
Phosphodiesterase Inhibitors
0
diethylstilbestrol monophosphate
47341-71-9
Phosphoric Diester Hydrolases
EC 3.1.4.-
Nucleotides, Cyclic
0
Cyclic GMP
H2D2X058MU
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
70-79Informations de copyright
© The Author(s) 2022. Published by Oxford University Press on behalf of CINP.
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