Left ventrolateral prefrontal cortical activity during reward expectancy predicts mania risk up to one year post scan.
Bipolar disorder
Bipolar disorder risk
Left ventrolateral prefrontal cortex
Mania
Reward expectancy
Reward sensitivity
Journal
Journal of affective disorders
ISSN: 1573-2517
Titre abrégé: J Affect Disord
Pays: Netherlands
ID NLM: 7906073
Informations de publication
Date de publication:
15 12 2022
15 12 2022
Historique:
received:
05
12
2021
revised:
19
05
2022
accepted:
22
08
2022
pubmed:
11
9
2022
medline:
16
11
2022
entrez:
10
9
2022
Statut:
ppublish
Résumé
Identification of neural markers associated with risk for manic symptoms is an important challenge for neuropsychiatric research. Previous work has highlighted the association between predisposition for mania/hypomania and elevated reward sensitivity. Elevated activity in the left ventrolateral prefrontal cortex (L vlPFC) during reward expectancy (RE) is associated with measures predictive of risk for manic/hypomanic symptoms. However, no studies have examined this relationship longitudinally. The goal of this study was to identify a neural marker associated with longitudinal risk for manic/hypomanic symptoms. We used a card guessing functional magnetic resonance imaging (fMRI) paradigm to examine RE-related L vlPFC activity. One hundred and three young adults who were either healthy or experiencing psychological distress completed a single baseline fMRI scan and self-report measures of manic/hypomanic symptoms. Self-report measures were repeated up to two follow up visits over one year. We identified a significant positive relationship between baseline RE-related L vlPFC activity and MOODS Manic Domain scores up to one-year post scan. This relationship was specific to manic symptoms and was not present for MOODS depression-related domains. This study was not designed to predict conversion to bipolar disorder, but rather the more proximal construct of lifetime risk for mania/hypomania. RE-related L vlPFC activity may serve as an important marker of risk for future manic/hypomanic symptoms and may also be a potential target for intervention.
Identifiants
pubmed: 36087789
pii: S0165-0327(22)00939-9
doi: 10.1016/j.jad.2022.08.081
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
325-328Subventions
Organisme : NIMH NIH HHS
ID : R01 MH100041
Pays : United States
Organisme : NIMH NIH HHS
ID : R37 MH100041
Pays : United States
Informations de copyright
Copyright © 2022 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Conflict of interest Dr. Fournier has or will receive royalties from Guilford Press (Cognitive Therapy for Personality Disorders, 3rd edition) and has received consulting fees from Happify, Inc. The other authors have no conflicts of interest to report.