Life-threatening hemophagocytic syndrome triggered by disseminated toxoplasmosis in a young patient with previously unknown AIDS.

Acquired Immunodeficiency Syndrome / complications Etoposide / therapeutic use HIV Infections / complications Humans Lymphohistiocytosis, Hemophagocytic / complications Male Toxoplasmosis / complications
Acquired Immunodeficiency Syndrome Critical care Immunocompromised Host Lymphohistiocytosis, Hemophagocytic Toxoplasmosis

Journal

La Revue de medecine interne
ISSN: 1768-3122
Titre abrégé: Rev Med Interne
Pays: France
ID NLM: 8101383

Informations de publication

Date de publication:
Oct 2022
Historique:
received: 03 03 2022
revised: 19 07 2022
accepted: 27 07 2022
pubmed: 12 9 2022
medline: 7 10 2022
entrez: 11 9 2022
Statut: ppublish

Résumé

Hemophagocytic syndrome is a rare life-threatening disorder that can be triggered by various conditions such as HIV infection and opportunistic agents. We report a case of disseminated toxoplasmosis complicated with severe hemophagocytic syndrome and revealing an unknown acquired immunodeficiency syndrome. The patient presented with multiple organ failure in intensive care unit. Once diagnosed, he benefitted from etoposide infusion, administration of specific anti-toxoplasmosis treatments and secondary antiretroviral therapy. He was alive at intensive care unit discharge and returned home with little sequalae. This case illustrates both the importance of rapid investigations of hemophagocytic syndrome etiologies in HIV positive patients and the necessity to prompt etoposide and specific treatments in order to improve potentially dramatic outcomes.

Identifiants

DOI: 10.1016/j.revmed.2022.07.016 PMID: 36089427
pubmed: 36089427
pii: S0248-8663(22)00603-8
doi: 10.1016/j.revmed.2022.07.016
pii:
doi:

Substances chimiques

Etoposide 6PLQ3CP4P3

Types de publication

Case Reports Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

622-625

Informations de copyright

Copyright © 2022 Société Nationale Française de Médecine Interne (SNFMI). Published by Elsevier Masson SAS. All rights reserved.

Auteurs

V Guiraud (V)

Université de Paris, AP-HP, hôpital Louis Mourier, DMU ESPRIT, médecine intensive réanimation, 92700 Colombes, France.

C Verney (C)

Université de Paris, AP-HP, hôpital Louis Mourier, DMU ESPRIT, médecine intensive réanimation, 92700 Colombes, France.

N Tetelboum (N)

Université de Paris, AP-HP, hôpital Louis Mourier, DMU DREAM, department of radiology, 92700 Colombes, France.

N Argy (N)

Université de Paris, AP-HP, Hôpital Bichat-Claude Bernard, DMU BIOGEM, Laboratoire de Parasitologie-Mycologie, 75018 Paris, France; Université de Paris, UMR 261 MERIT, IRD, faculté de pharmacie, 75006 Paris, France.

J Debus (J)

Université de Paris, AP-HP, hôpital Louis Mourier, DMU BIOGEM, hématologie biologique et transfusion, 92700 Colombes, France.

S Herbel (S)

Université de Paris, AP-HP, hôpital Bichat-Claude Bernard, DMU INVICTUS, service de maladies infectieuses et tropicales, 75018 Paris, France.

M Thy (M)

Université de Paris, AP-HP, hôpital Bichat-Claude Bernard, DMU INVICTUS, service de maladies infectieuses et tropicales, 75018 Paris, France.

J D Ricard (JD)

Université de Paris, AP-HP, hôpital Louis Mourier, DMU ESPRIT, médecine intensive réanimation, 92700 Colombes, France; Université de Paris, UMR 1137 IAME, Inserm, 75018 Paris, France.

D Roux (D)

Université de Paris, AP-HP, hôpital Louis Mourier, DMU ESPRIT, médecine intensive réanimation, 92700 Colombes, France; Université de Paris, institut Necker-Enfants Malades, Inserm U1151, CNRS UMR 8253, 75015 Paris, France.

N Zucman (N)

Université de Paris, AP-HP, hôpital Louis Mourier, DMU ESPRIT, médecine intensive réanimation, 92700 Colombes, France. Electronic address: noemie.zucman@gmail.com.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Maladies du système immunitaire › Déficits immunitaires › Infections à VIH › Syndrome d'immunodéficience acquise › Life-threatening hemophagocytic syndrome...
questionsmedicales.fr › Glucides › Hétérosides › Glucosides › Étoposide › Life-threatening hemophagocytic syndrome...
questionsmedicales.fr › Maladies du système immunitaire › Déficits immunitaires › Infections à VIH › Life-threatening hemophagocytic syndrome...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Life-threatening hemophagocytic syndrome...
questionsmedicales.fr › Hémopathies et maladies lymphatiques › Maladies lymphatiques › Histiocytose › Histiocytose non langerhansienne › Lymphohistiocytose hémophagocytaire › Life-threatening hemophagocytic syndrome...
questionsmedicales.fr › Infection › Maladies parasitaires › Protozooses › Coccidiose › Toxoplasmose › Life-threatening hemophagocytic syndrome...