Cardiovascular magnetic resonance imaging and spectroscopy in clinical long-COVID-19 syndrome: a prospective case-control study.
31-phosphorus magnetic resonance spectroscopy
COVID-19
Cardiovascular magnetic resonance imaging
LONG COVID
Post-COVID-19 syndrome
Journal
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
ISSN: 1532-429X
Titre abrégé: J Cardiovasc Magn Reson
Pays: England
ID NLM: 9815616
Informations de publication
Date de publication:
12 09 2022
12 09 2022
Historique:
received:
02
06
2022
accepted:
30
08
2022
entrez:
11
9
2022
pubmed:
12
9
2022
medline:
14
9
2022
Statut:
epublish
Résumé
The underlying pathophysiology of post-coronavirus disease 2019 (long-COVID-19) syndrome remains unknown, but increased cardiometabolic demand and state of mitochondrial dysfunction have emerged as candidate mechanisms. Cardiovascular magnetic resonance (CMR) provides insight into pathophysiological mechanisms underlying cardiovascular disease and 31-phosphorus CMR spectroscopy ( Prospective case-control study. A total of 20 patients with a clinical diagnosis of long COVID-19 syndrome (seropositive) and no prior underlying cardiovascular disease (CVD) and 10 matching healthy controls underwent Between the long COVID-19 syndrome patients and matched contemporary healthy controls there were no differences in myocardial energetics (phosphocreatine to ATP ratio), in cardiac structure (biventricular volumes), function (biventricular ejection fractions, global longitudinal strain), tissue characterization (T In this prospective case-control study, the overwhelming majority of patients with a clinical long COVID-19 syndrome with no prior CVD did not exhibit any abnormalities in myocardial energetics, structure, function, blood flow or tissue characteristics.
Sections du résumé
BACKGROUND
The underlying pathophysiology of post-coronavirus disease 2019 (long-COVID-19) syndrome remains unknown, but increased cardiometabolic demand and state of mitochondrial dysfunction have emerged as candidate mechanisms. Cardiovascular magnetic resonance (CMR) provides insight into pathophysiological mechanisms underlying cardiovascular disease and 31-phosphorus CMR spectroscopy (
METHODS
Prospective case-control study. A total of 20 patients with a clinical diagnosis of long COVID-19 syndrome (seropositive) and no prior underlying cardiovascular disease (CVD) and 10 matching healthy controls underwent
RESULTS
Between the long COVID-19 syndrome patients and matched contemporary healthy controls there were no differences in myocardial energetics (phosphocreatine to ATP ratio), in cardiac structure (biventricular volumes), function (biventricular ejection fractions, global longitudinal strain), tissue characterization (T
CONCLUSIONS
In this prospective case-control study, the overwhelming majority of patients with a clinical long COVID-19 syndrome with no prior CVD did not exhibit any abnormalities in myocardial energetics, structure, function, blood flow or tissue characteristics.
Identifiants
pubmed: 36089591
doi: 10.1186/s12968-022-00887-9
pii: 10.1186/s12968-022-00887-9
pmc: PMC9464490
doi:
Substances chimiques
Contrast Media
0
Gadolinium
AU0V1LM3JT
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
50Subventions
Organisme : Medical Research Council
ID : MC_PC_20014
Pays : United Kingdom
Organisme : Welcome Trust Clinical Career Development Fellowship
ID : 221690/Z/20/Z
Organisme : National Institute for Health Research
ID : COV0254
Informations de copyright
© 2022. The Author(s).
Références
Am Heart J Plus. 2021 May;5:100025
pubmed: 34192289
Eur Heart J. 2013 Jan;34(4):292-9
pubmed: 23053174
J Cardiovasc Magn Reson. 2017 Apr 7;19(1):43
pubmed: 28385161
J Am Coll Cardiol. 2018 Dec 18;72(24):3158-3176
pubmed: 30545455
J Cardiovasc Magn Reson. 2013 Oct 08;15:91
pubmed: 24103764
EClinicalMedicine. 2021 Jan 07;31:100683
pubmed: 33490928
J Cardiovasc Magn Reson. 2020 Feb 24;22(1):17
pubmed: 32089132
Physiol Rev. 2010 Jan;90(1):207-58
pubmed: 20086077
Circulation. 2021 Jul 27;144(4):256-266
pubmed: 33866822
EBioMedicine. 2020 Jun;56:102784
pubmed: 32454403
J Cardiovasc Magn Reson. 2017 Dec 4;19(1):96
pubmed: 29202847
Radiol Artif Intell. 2021 Jul 14;3(5):e200197
pubmed: 34617022
Lancet Child Adolesc Health. 2021 Jun;5(6):e22-e23
pubmed: 33891880
Nat Clin Pract Cardiovasc Med. 2008 Aug;5 Suppl 2:S49-56
pubmed: 18641607
J Am Heart Assoc. 2017 Jul 17;6(7):
pubmed: 28716801
Nat Med. 2021 Sep;27(9):1607-1613
pubmed: 34163090
NMR Biomed. 2009 May;22(4):405-13
pubmed: 19023865
JACC Cardiovasc Imaging. 2021 Nov;14(11):2155-2166
pubmed: 33975819
N Engl J Med. 2007 Mar 15;356(11):1140-51
pubmed: 17360992
Lancet Infect Dis. 2021 Oct;21(10):1373-1382
pubmed: 33984263
Circ Cardiovasc Imaging. 2013 May 1;6(3):423-32
pubmed: 23599309
Heart. 2022 Jan;108(1):46-53
pubmed: 34615668
J Cardiovasc Magn Reson. 2012 Sep 10;14:63
pubmed: 22963517
J Am Heart Assoc. 2017 Mar 31;6(4):
pubmed: 28364045
Lancet Reg Health Eur. 2021 Jul;6:100122
pubmed: 34027514
Magn Reson Med. 2004 Jul;52(1):141-6
pubmed: 15236377
Nat Med. 2021 Apr;27(4):601-615
pubmed: 33753937
Diabetes. 2021 Dec;70(12):2810-2822
pubmed: 34610982
J Cardiovasc Magn Reson. 2009 Dec 30;11:56
pubmed: 20042111