Phosphatidylserine Regulation of Coagulation Proteins Factor IXa and Factor VIIIa.
Coagulation
Factor IXa
Factor Xa
Phosphatidylserine
Protein S
Journal
The Journal of membrane biology
ISSN: 1432-1424
Titre abrégé: J Membr Biol
Pays: United States
ID NLM: 0211301
Informations de publication
Date de publication:
12 2022
12 2022
Historique:
received:
26
03
2022
accepted:
09
08
2022
pubmed:
14
9
2022
medline:
22
11
2022
entrez:
13
9
2022
Statut:
ppublish
Résumé
Blood coagulation is an intricate process, and it requires precise control of the activities of pro- and anticoagulant factors and sensitive signaling systems to monitor and respond to blood vessel insults. These requirements are fulfilled by phosphatidylserine, a relatively miniscule-sized lipid molecule amid the myriad of large coagulation proteins. This review limelight the role of platelet membrane phosphatidylserine (PS) in regulating a key enzymatic reaction of blood coagulation; conversion of factor X to factor Xa by the enzyme factor IXa and its cofactor factor VIIIa. PS is normally located on the inner leaflet of the resting platelet membrane but appears on the outer leaflet surface of the membrane surface after an injury happens. Human platelet activation leads to exposure of buried PS molecules on the surface of the platelet-derived membranes and the exposed PS binds to discrete and specific sites on factors IXa and VIIIa. PS binding to these sites allosterically regulates both factors IXa and VIIIa. The exposure of PS and its binding to factors IXa/VIIIa is a vital step during clotting. Insufficient exposure or a defective binding of PS to these clotting proteins is responsible for various hematologic diseases which are discussed in this review.
Identifiants
pubmed: 36098799
doi: 10.1007/s00232-022-00265-7
pii: 10.1007/s00232-022-00265-7
doi:
Substances chimiques
Factor VIIIa
72175-66-7
Factor IXa
EC 3.4.21.22
Phosphatidylserines
0
Factor X
9001-29-0
Factor Xa
EC 3.4.21.6
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
733-737Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL118557
Pays : United States
Informations de copyright
© 2022. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.
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