Factors, associated with elevated concentration of soluble carbonic anhydrase IX in plasma of women with cervical dysplasia.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
13 Sep 2022
13 Sep 2022
Historique:
received:
01
02
2022
accepted:
30
08
2022
entrez:
13
9
2022
pubmed:
14
9
2022
medline:
16
9
2022
Statut:
epublish
Résumé
Precancerous lesions of human cervix uteri have a tendency for regression or progression. In cervical intraepithelial neoplasia grade 2 (CINII) case there is an uncertainty if a lesion will progress or regress. The carbonic anhydrase IX (CAIX) enzyme is overexpressed in cervical cancer which is more sensitive to radiotherapy. CAIX is associated with poor prognosis in solid hypoxic tumors. The aim of this study was to determine factors related to elevated soluble CAIX (s-CAIX) in high-grade intraepithelial lesion (HSIL) cases. Patients diagnosed with HSIL (N = 77) were included into the research group whereas without HSIL (N = 72)-the control group. Concentration of the soluble CAIX (s-CAIX) in plasma was determined by the DIANA ligand-antibody-based method. C. trachomatis was detected from cervical samples by PCR. Primary outcomes were risk factors elevating s-CAIX level in HSIL group. Non-parametric statistical analysis methods were used to calculate correlations. The s-CAIX level in patients with HSIL was elevated among older participants (r The concentration of s-CAIX was higher among older, heavy smoking and diagnosed with C. trachomatis patients. All these factors increased the risk for HSIL progression.
Identifiants
pubmed: 36100684
doi: 10.1038/s41598-022-19492-y
pii: 10.1038/s41598-022-19492-y
pmc: PMC9470728
doi:
Substances chimiques
Antigens, Neoplasm
0
CA9 protein, human
EC 4.2.1.1
Carbonic Anhydrase IX
EC 4.2.1.1
Carbonic Anhydrases
EC 4.2.1.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
15397Informations de copyright
© 2022. The Author(s).
Références
Int J Cancer. 2007 Feb 1;120(3):650-5
pubmed: 17096345
Chin J Cancer Res. 2020 Dec 31;32(6):720-728
pubmed: 33446995
J Infect Dis. 2019 Jan 7;219(2):206-214
pubmed: 30192954
Acta Cytol. 2017;61(6):434-440
pubmed: 28738387
Cancer Res. 2001 Jul 1;61(13):5262-7
pubmed: 11431368
Cancer. 1997 Oct 25;81(5):272-6
pubmed: 9349513
Br J Cancer. 2011 Jan 18;104(2):353-60
pubmed: 21157448
Oncogene. 2018 Aug;37(31):4214-4225
pubmed: 29713057
Obstet Gynecol. 2010 Nov;116(5):1158-70
pubmed: 20966702
Int J Gynecol Cancer. 2011 Jan;21(1):141-8
pubmed: 21330838
Lancet Oncol. 2008 May;9(5):425-34
pubmed: 18407790
BMC Pregnancy Childbirth. 2016 Apr 07;16:74
pubmed: 27055819
Lancet. 2020 Feb 22;395(10224):575-590
pubmed: 32007141
Exp Mol Med. 2019 Jun 20;51(6):1-15
pubmed: 31221957
J Clin Microbiol. 1993 May;31(5):1060-5
pubmed: 8099080
Br J Cancer. 2020 May;122(11):1577-1579
pubmed: 32242099
Dis Markers. 2013;35(6):721-6
pubmed: 24324288
Int J Cancer. 2019 Aug 1;145(3):857-868
pubmed: 30694523
Br J Cancer. 2003 Sep 15;89(6):1067-71
pubmed: 12966427
Cancer Metastasis Rev. 2019 Jun;38(1-2):65-77
pubmed: 31076951
Oncogene. 1994 Oct;9(10):2877-88
pubmed: 8084592
Subcell Biochem. 2014;75:3-5
pubmed: 24146371
Viruses. 2017 Sep 01;9(9):
pubmed: 28862667
Br J Cancer. 2010 May 25;102(11):1627-35
pubmed: 20461082
J Natl Cancer Inst. 1999 Feb 3;91(3):252-8
pubmed: 10037103
Microbiology (Reading). 2017 May;163(5):654-663
pubmed: 28535856
Gynecol Oncol. 2010 Mar;116(3):452-8
pubmed: 19913895
Oncotarget. 2016 Mar 22;7(12):15230-42
pubmed: 26885692
Br J Cancer. 2012 Sep 25;107(7):1131-7
pubmed: 22918393
Am J Pathol. 2007 Aug;171(2):667-81
pubmed: 17600126
Eur J Cancer. 1995 Sep;31A(10):1672-6
pubmed: 7488423
Am J Pathol. 1998 Jul;153(1):279-85
pubmed: 9665489
Obstet Gynecol. 2012 Dec;120(6):1465-71
pubmed: 23168774
J Transl Med. 2013 Aug 08;11:185
pubmed: 23927384
Pathol Oncol Res. 2016 Apr;22(2):277-86
pubmed: 26224207
Metabolites. 2018 Feb 10;8(1):
pubmed: 29439394
Obstet Gynecol. 2016 Dec;128(6):1265-1273
pubmed: 27824756
Zhongguo Fei Ai Za Zhi. 2015 Jan;18(1):29-33
pubmed: 25603870
Neoplasma. 2009;56(4):298-302
pubmed: 19473055
Am J Obstet Gynecol. 2011 Jul;205(1):19-27
pubmed: 21345402
Papillomavirus Res. 2017 Jun;3:30-35
pubmed: 28720454
BMJ. 1991 Jun 8;302(6789):1361-5
pubmed: 2059713
Dis Markers. 2016;2016:9810383
pubmed: 26941473
ISRN Obstet Gynecol. 2011;2011:847684
pubmed: 21785734
J Natl Cancer Inst. 2003 Sep 3;95(17):1336-43
pubmed: 12953088
Am J Stem Cells. 2019 Dec 15;8(3):52-64
pubmed: 31976155
Int J Cancer. 2012 Dec 1;131(11):2519-27
pubmed: 22447412
Eur J Cardiothorac Surg. 2014 Jul;46(1):92-9
pubmed: 24321995
Obstet Gynecol Sci. 2015 Mar;58(2):117-23
pubmed: 25798425
Am J Obstet Gynecol. 2003 Jun;188(6):1406-12
pubmed: 12824970
CA Cancer J Clin. 2018 Nov;68(6):394-424
pubmed: 30207593
Neoplasma. 2014;61(2):161-9
pubmed: 24471939
Jpn J Clin Oncol. 2007 Nov;37(11):812-9
pubmed: 18057013
J Med Virol. 2015 Mar;87(3):461-71
pubmed: 25196501
Int J Cancer. 1986 Oct 15;38(4):489-94
pubmed: 2428759
Transgenic Res. 2012 Feb;21(1):163-76
pubmed: 21547424
Am J Clin Pathol. 2014 Jul;142(1):82-7
pubmed: 24926090
Medicine (Baltimore). 2016 Mar;95(13):e3077
pubmed: 27043670