Micellar Curcumin: Pharmacokinetics and Effects on Inflammation Markers and PCSK-9 Concentrations in Healthy Subjects in a Double-Blind, Randomized, Active-Controlled, Crossover Trial.
PCSK9
TNF-α
curcumin
inflammation
interleukin-6
lipopolysaccharide
pharmacokinetics
Journal
Molecular nutrition & food research
ISSN: 1613-4133
Titre abrégé: Mol Nutr Food Res
Pays: Germany
ID NLM: 101231818
Informations de publication
Date de publication:
11 2022
11 2022
Historique:
revised:
23
07
2022
received:
01
03
2022
pubmed:
15
9
2022
medline:
24
11
2022
entrez:
14
9
2022
Statut:
ppublish
Résumé
Preclinical models have demonstrated the anti-inflammatory and lipid-lowering effects of curcumin. Innovative formulations have been developed to overcome the poor bioavailability of native curcumin. The study hypothesizes that the bioavailability of micellar curcumin is superior to native curcumin and investigates the potential anti-inflammatory and proprotein convertase subtilisin/kexin type 9 (PCSK9) concentration lowering effects. In this double-blind, randomized, crossover trial, 15 healthy volunteers receive micellar or native curcumin (105 mg day Micellar curcumin demonstrates an improved oral bioavailability but does not show anti-inflammatory effects in this model. Potential effects on PCSK9 concentrations warrant further investigation.
Identifiants
pubmed: 36101515
doi: 10.1002/mnfr.202200139
pmc: PMC9787856
doi:
Substances chimiques
PCSK9 protein, human
EC 3.4.21.-
Proprotein Convertase 9
EC 3.4.21.-
Curcumin
IT942ZTH98
Micelles
0
Anti-Inflammatory Agents
0
Biomarkers
0
Interleukin-6
0
Types de publication
Randomized Controlled Trial
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2200139Informations de copyright
© 2022 The Authors. Molecular Nutrition & Food Research published by Wiley-VCH GmbH.
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