Synaptotagmin rings as high-sensitivity regulators of synaptic vesicle docking and fusion.

Adenosine Triphosphate / metabolism Calcium / metabolism Phosphatidylinositol 4,5-Diphosphate / chemistry Synaptic Vesicles / metabolism Synaptotagmin I / chemistry
membrane fusion neurotransmitter release synapse synaptotagmin vesicle docking

Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
20 09 2022
Historique:
entrez: 14 9 2022
pubmed: 15 9 2022
medline: 17 9 2022
Statut: ppublish

Résumé

Synchronous release at neuronal synapses is accomplished by a machinery that senses calcium influx and fuses the synaptic vesicle and plasma membranes to release neurotransmitters. Previous studies suggested the calcium sensor synaptotagmin (Syt) is a facilitator of vesicle docking and both a facilitator and inhibitor of fusion. On phospholipid monolayers, the Syt C2AB domain spontaneously oligomerized into rings that are disassembled by Ca

Identifiants

DOI: 10.1073/pnas.2208337119 PMID: 36103579 PMC: PMC9499556
pubmed: 36103579
doi: 10.1073/pnas.2208337119
pmc: PMC9499556
doi:

Substances chimiques

Phosphatidylinositol 4,5-Diphosphate 0
Synaptotagmin I 0
Adenosine Triphosphate 8L70Q75FXE
Calcium SY7Q814VUP

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2208337119

Subventions

Organisme : NIGMS NIH HHS
ID : R01 GM117046
Pays : United States

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Auteurs

Jie Zhu (J)

Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06520.

Zachary A McDargh (ZA)

Department of Chemical Engineering, Columbia University, New York, NY 10027.

Feng Li (F)

Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06520.
ORCID: 0000-0003-1799-9570

Shyam S Krishnakumar (SS)

Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06520.
ORCID: 0000-0001-6148-3251

James E Rothman (JE)

Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06520.
ORCID: 0000-0003-4822-4161

Ben O'Shaughnessy (B)

Department of Chemical Engineering, Columbia University, New York, NY 10027.

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Classifications MeSH

questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléotides adényliques › Adénosine triphosphate › Synaptotagmin rings as high-sensitivity...
questionsmedicales.fr › Facteurs biologiques › Facteurs de la coagulation sanguine › Calcium › Synaptotagmin rings as high-sensitivity...
questionsmedicales.fr › Lipides › Lipides membranaires › Phospholipides › Glycérophosphate › Acides phosphatidiques › Glycérophospholipides › Phosphatidyl inositols › Phosphates phosphatidylinositol › Phosphatidylinositol diphosphate-4,5 › Synaptotagmin rings as high-sensitivity...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Vésicules cytoplasmiques › Vésicules de transport › Vésicules de sécrétion › Vésicules synaptiques › Synaptotagmin rings as high-sensitivity...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines du transport vésiculaire › Synaptotagmines › Synaptotagmine I › Synaptotagmin rings as high-sensitivity...