Structural magnetic resonance imaging findings and histopathological correlations in motor neuron diseases-A systematic review and meta-analysis.
amyotrophic lateral sclerosis
magnetic resonance imaging (MRI)
meta-analysis
motor neuron disease
neuroimaging
systematic review
Journal
Frontiers in neurology
ISSN: 1664-2295
Titre abrégé: Front Neurol
Pays: Switzerland
ID NLM: 101546899
Informations de publication
Date de publication:
2022
2022
Historique:
received:
18
05
2022
accepted:
08
07
2022
entrez:
16
9
2022
pubmed:
17
9
2022
medline:
17
9
2022
Statut:
epublish
Résumé
The lack of systematic evidence on neuroimaging findings in motor neuron diseases (MND) hampers the diagnostic utility of magnetic resonance imaging (MRI). Thus, we aimed at performing a systematic review and meta-analysis of MRI features in MND including their histopathological correlation. In a comprehensive literature search, out of 5941 unique publications, 223 records assessing brain and spinal cord MRI findings in MND were eligible for a qualitative synthesis. 21 records were included in a random effect model meta-analysis. Our meta-analysis shows that both T2-hyperintensities along the corticospinal tracts (CST) and motor cortex T2 Although CST T2-hyperintensities and the "motor band sign" are non-specific imaging features, they can be leveraged for diagnostic workup of suspected MND cases, together with certain brain atrophy patterns. Collectively, this study provides high-grade evidence for the usefulness of MRI in the diagnostic workup of suspected MND cases. https://www.crd.york.ac.uk/PROSPERO/, identifier: CRD42020182682.
Identifiants
pubmed: 36110394
doi: 10.3389/fneur.2022.947347
pmc: PMC9468579
doi:
Types de publication
Systematic Review
Langues
eng
Pagination
947347Informations de copyright
Copyright © 2022 Zejlon, Nakhostin, Winklhofer, Pangalu, Kulcsar, Lewandowski, Finnsson, Piehl, Ingre, Granberg and Ineichen.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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