High physical activity and ovarian reserve: a prospective study of normo-ovulatory professional athletes.
Anti-Mullerian hormone
Antral follicle count
Athletes
Follicle stimulating hormone
High physical activity
Ovarian reserve
Journal
Journal of ovarian research
ISSN: 1757-2215
Titre abrégé: J Ovarian Res
Pays: England
ID NLM: 101474849
Informations de publication
Date de publication:
16 Sep 2022
16 Sep 2022
Historique:
received:
12
06
2022
accepted:
26
08
2022
entrez:
16
9
2022
pubmed:
17
9
2022
medline:
21
9
2022
Statut:
epublish
Résumé
This study investigated whether high physical activity affects ovarian reserve in normo-ovulatory, reproductive-age women. This prospective, observational study compared 31 professional female athletes, with 31 women who did not engage in physical activity. It was conducted 2017-2020 in a tertiary medical center. Normo-ovulatory, professional athletes, ages 20-35 years were recruited from The Wingate Institute-the Israeli National Institute for Sport Excellence. They had high International Physical Activity Questionnaire (IPAQ) scores. Non-physically active women, matched by age and body mass index, were recruited from hospital staff. Women were evaluated for ovarian reserve markers on day 2-5 of the menstrual cycle, including follicular stimulating hormone, antral follicle count, anti-Mullerian hormone and Inhibin B. The average age of the high physical activity group was 29.9 ± 4.2 years and the nonactive group 31.6 ± 4.2 years (p = 0.062). Body mass index of both groups were similar (22.5 ± 5.0 vs. 21.4 ± 2.5, respectively; p = 0.1). No differences were observed with respect to follicle stimulating hormone (p = 0.12) and anti-Mullerian hormone (p = 0.16). A trend towards higher total antral follicle count in the high physical activity group vs. the non-active group (34.5 ± 12.9 vs. 28.1 ± 15.2, p = 0.08) and lower Inhibin B (68.1 ± 36.8 vs. 89.4 ± 46.1, p = 0.05). Menarche age correlated with anti-Mullerian hormone (r = 0.387, p = 0.003), as did total antral follicle count (r = 0.368, p = 0.004). IPAQ scores and basal follicle stimulating hormone levels were negatively correlated (r = - 0.292, p = 0.005). Athletic, normo-ovulatory women have ovarian reserves that are at least as good as those of the general population. As this is the first study examining this issue, it could cautiously reassure women engaged in high physical activity regarding ovarian reserve.
Sections du résumé
BACKGROUND
BACKGROUND
This study investigated whether high physical activity affects ovarian reserve in normo-ovulatory, reproductive-age women.
METHODS
METHODS
This prospective, observational study compared 31 professional female athletes, with 31 women who did not engage in physical activity. It was conducted 2017-2020 in a tertiary medical center. Normo-ovulatory, professional athletes, ages 20-35 years were recruited from The Wingate Institute-the Israeli National Institute for Sport Excellence. They had high International Physical Activity Questionnaire (IPAQ) scores. Non-physically active women, matched by age and body mass index, were recruited from hospital staff. Women were evaluated for ovarian reserve markers on day 2-5 of the menstrual cycle, including follicular stimulating hormone, antral follicle count, anti-Mullerian hormone and Inhibin B.
RESULTS
RESULTS
The average age of the high physical activity group was 29.9 ± 4.2 years and the nonactive group 31.6 ± 4.2 years (p = 0.062). Body mass index of both groups were similar (22.5 ± 5.0 vs. 21.4 ± 2.5, respectively; p = 0.1). No differences were observed with respect to follicle stimulating hormone (p = 0.12) and anti-Mullerian hormone (p = 0.16). A trend towards higher total antral follicle count in the high physical activity group vs. the non-active group (34.5 ± 12.9 vs. 28.1 ± 15.2, p = 0.08) and lower Inhibin B (68.1 ± 36.8 vs. 89.4 ± 46.1, p = 0.05). Menarche age correlated with anti-Mullerian hormone (r = 0.387, p = 0.003), as did total antral follicle count (r = 0.368, p = 0.004). IPAQ scores and basal follicle stimulating hormone levels were negatively correlated (r = - 0.292, p = 0.005).
CONCLUSIONS
CONCLUSIONS
Athletic, normo-ovulatory women have ovarian reserves that are at least as good as those of the general population. As this is the first study examining this issue, it could cautiously reassure women engaged in high physical activity regarding ovarian reserve.
Identifiants
pubmed: 36114550
doi: 10.1186/s13048-022-01040-x
pii: 10.1186/s13048-022-01040-x
pmc: PMC9482187
doi:
Substances chimiques
Anti-Mullerian Hormone
80497-65-0
Follicle Stimulating Hormone
9002-68-0
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
107Informations de copyright
© 2022. The Author(s).
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