Evaluation of the oxytocin effect in a rat model with experimental periodontitis.
Alveolar bone loss
Antioxidant
Oxytocin
Periodontal diseases
Rats
Journal
Naunyn-Schmiedeberg's archives of pharmacology
ISSN: 1432-1912
Titre abrégé: Naunyn Schmiedebergs Arch Pharmacol
Pays: Germany
ID NLM: 0326264
Informations de publication
Date de publication:
12 2022
12 2022
Historique:
received:
24
05
2022
accepted:
08
09
2022
pubmed:
18
9
2022
medline:
5
11
2022
entrez:
17
9
2022
Statut:
ppublish
Résumé
The aim of the present study was to evaluate the inhibitory effects of oxytocin on the development of periodontitis based on its properties against bone loss and resorption. Thirty-two Wistar albino rats were divided into four equal groups: control, periodontitis + saline, periodontitis + 0.5 mg/kg/day oxytocin, and periodontitis + 1 mg/kg/day oxytocin. Periodontitis groups received 4.0 silk ligatures around their cervixes of the right and left mandibular incisors in an "8" shape, kept for 14 days. Animals in oxytocin groups were injected once every day during 14 days with oxytocin. The mandibles were fixed and scanned using microcomputed tomography to quantify bone resorption and volumetric measurements. Blood samples were collected to analyze the concentrations of macrophage colony-stimulating factor (M-CSF), receptor activator of nuclear factor-κΒ ligand (RANKL), osteoprotegerin (OPG), matrix metalloproteinase-8 (MMP-8), tumor necrosis factor-alpha (TNF-α), interleukin (IL)-6, glutathione peroxidase (GPx), superoxide dismutase (SOD), and malondialdehyde (MDA). Histopathological evaluations were conducted to examine the gingiva and alveolar bone. Oxytocin prevented the development of periodontitis by decreasing ligament deteriorations and leukocytes in the gingival connective tissue and promoting reintegration with the alveolar bone. Bone resorption in all regions was less in the periodontitis + 1 mg/kg/day oxytocin group than in the periodontitis + saline group. Although TNF-α, IL-6, and RANKL values were lower in the periodontitis + 1 mg/kg/day oxytocin group, OPG was higher than that in the periodontitis + saline group. M-CSF, MMP-8, and MDA were lower in the oxytocin groups than in the periodontitis + saline group. Oxytocin may be an effective agent for periodontal diseases because it decreased bone resorption, oxidative stress, and inflammation in an experimental periodontitis.
Identifiants
pubmed: 36114855
doi: 10.1007/s00210-022-02293-5
pii: 10.1007/s00210-022-02293-5
doi:
Substances chimiques
Matrix Metalloproteinase 8
EC 3.4.24.34
Oxytocin
50-56-6
Macrophage Colony-Stimulating Factor
81627-83-0
Tumor Necrosis Factor-alpha
0
RANK Ligand
0
Interleukin-1beta
0
Osteoprotegerin
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1599-1608Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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