Stability of motor representations after paralysis.
brain-machine interface
brain–computer interface
fingers
hand
human
neuroscience
paralysis
plasticity
posterior parietal cortex
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
20 09 2022
20 09 2022
Historique:
received:
06
10
2021
accepted:
27
08
2022
pubmed:
21
9
2022
medline:
15
10
2022
entrez:
20
9
2022
Statut:
epublish
Résumé
Neural plasticity allows us to learn skills and incorporate new experiences. What happens when our lived experiences fundamentally change, such as after a severe injury? To address this question, we analyzed intracortical population activity in the posterior parietal cortex (PPC) of a tetraplegic adult as she controlled a virtual hand through a brain-computer interface (BCI). By attempting to move her fingers, she could accurately drive the corresponding virtual fingers. Neural activity during finger movements exhibited robust representational structure similar to fMRI recordings of able-bodied individuals' motor cortex, which is known to reflect able-bodied usage patterns. The finger representational structure was consistent throughout multiple sessions, even though the structure contributed to BCI decoding errors. Within individual BCI movements, the representational structure was dynamic, first resembling muscle activation patterns and then resembling the anticipated sensory consequences. Our results reveal that motor representations in PPC reflect able-bodied motor usage patterns even after paralysis, and BCIs can re-engage these stable representations to restore lost motor functions.
Identifiants
pubmed: 36125116
doi: 10.7554/eLife.74478
pii: 74478
pmc: PMC9555862
doi:
pii:
Banques de données
ClinicalTrials.gov
['NCT01958086']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NEI NIH HHS
ID : R01 EY015545
Pays : United States
Organisme : NEI NIH HHS
ID : UG1 EY032039
Pays : United States
Informations de copyright
© 2022, Guan, Aflalo et al.
Déclaration de conflit d'intérêts
CG, TA, CZ, EA, ER, NP, RA No competing interests declared
Références
Philos Trans R Soc Lond B Biol Sci. 2016 Oct 5;371(1705):
pubmed: 27574316
Nature. 2001 Jul 12;412(6843):150-7
pubmed: 11449264
Cell. 2020 Apr 16;181(2):396-409.e26
pubmed: 32220308
Neurology. 2022 Feb 15;98(7):e679-e687
pubmed: 34880087
Front Syst Neurosci. 2008 Nov 24;2:4
pubmed: 19104670
Neuron. 2019 May 8;102(3):694-705.e3
pubmed: 30853300
J Neurosci. 1982 Nov;2(11):1527-37
pubmed: 7143039
J Neurosci. 2017 Feb 15;37(7):1721-1732
pubmed: 28087767
Neuron. 2018 Jan 3;97(1):209-220.e3
pubmed: 29249283
Curr Opin Neurobiol. 2015 Aug;33:141-9
pubmed: 25876179
Trends Cogn Sci. 2000 Nov 1;4(11):423-431
pubmed: 11058820
J Neurophysiol. 2004 Nov;92(5):2802-10
pubmed: 15212429
Elife. 2020 Nov 17;9:
pubmed: 33200745
Nat Commun. 2014 Apr 08;5:3602
pubmed: 24710038
Lancet. 2017 May 6;389(10081):1821-1830
pubmed: 28363483
Science. 2015 May 22;348(6237):906-10
pubmed: 25999506
Science. 1991 Jun 28;252(5014):1857-60
pubmed: 1843843
Brain Struct Funct. 2013 May;218(3):611-43
pubmed: 23129312
Neuron. 2017 Aug 2;95(3):697-708.e4
pubmed: 28735750
Brain Res. 2013 Apr 4;1504:58-73
pubmed: 23396112
Nature. 2006 Jul 13;442(7099):164-71
pubmed: 16838014
Proc Natl Acad Sci U S A. 2019 Jul 23;116(30):15210-15215
pubmed: 31182595
Nature. 2014 Aug 28;512(7515):423-6
pubmed: 25164754
Nat Neurosci. 2011 May;14(5):649-55
pubmed: 21441924
Elife. 2019 Feb 05;8:
pubmed: 30717824
PLoS Comput Biol. 2017 Apr 24;13(4):e1005508
pubmed: 28437426
Neuron. 2018 Mar 7;97(5):1177-1186.e3
pubmed: 29456026
Lancet. 2013 Feb 16;381(9866):557-64
pubmed: 23253623
J Neural Eng. 2018 Apr;15(2):026007
pubmed: 29363625
Sci Robot. 2021 May 19;6(54):
pubmed: 34043536
J Neural Eng. 2016 Apr;13(2):026017-26017
pubmed: 26863276
Front Psychol. 2014 Apr 09;5:310
pubmed: 24782809
Neuropsychologia. 2016 Mar;83:201-226
pubmed: 26493748
Neuron. 2013 Jan 9;77(1):168-79
pubmed: 23312524
Neuroimage. 2018 Oct 1;179:337-347
pubmed: 29940282
Front Psychol. 2014 Jul 29;5:781
pubmed: 25120503
Trends Neurosci. 2016 Aug;39(8):512-526
pubmed: 27378546
Nat Neurosci. 2015 Jul;18(7):1034-40
pubmed: 26030847
Neuron. 2012 Dec 20;76(6):1071-7
pubmed: 23259944
J Neurosci. 2008 Oct 22;28(43):11042-60
pubmed: 18945912
Science. 1969 Feb 28;163(3870):955-8
pubmed: 4974291
Nature. 1992 Mar 12;356(6365):150-2
pubmed: 1545866
Neuron. 2008 Dec 26;60(6):1126-41
pubmed: 19109916
Nature. 2016 Apr 13;533(7602):247-50
pubmed: 27074513
Elife. 2018 Apr 10;7:
pubmed: 29633714
Brain. 1997 Jan;120 ( Pt 1):141-57
pubmed: 9055804
J Neurophysiol. 2000 Oct;84(4):2133-47
pubmed: 11024101
Nat Med. 2015 Oct;21(10):1142-5
pubmed: 26413781
Elife. 2016 Aug 23;5:
pubmed: 27552053
J Neurophysiol. 2000 May;83(5):2580-601
pubmed: 10805659
Proc Natl Acad Sci U S A. 2022 Mar 29;119(13):e2118903119
pubmed: 35312363
J Comput Neurosci. 2008 Aug;25(1):169-87
pubmed: 18236147
J Neurosci. 2015 Nov 18;35(46):15466-76
pubmed: 26586832
Curr Opin Neurobiol. 2022 Jun;74:102547
pubmed: 35533644
Nat Neurosci. 2014 Jun;17(6):807-809
pubmed: 24728268
Elife. 2021 Oct 19;10:
pubmed: 34665133
Neurosurgery. 2020 Sep 15;87(4):630-638
pubmed: 32140722
Nat Neurosci. 1998 Oct;1(6):529-33
pubmed: 10196553
Nature. 2012 Jul 5;487(7405):51-6
pubmed: 22722855
Nat Methods. 2019 Jul;16(7):565-566
pubmed: 31217592
Nature. 2012 May 16;485(7398):372-5
pubmed: 22596161
Proc Natl Acad Sci U S A. 2008 Jun 17;105(24):8170-7
pubmed: 18499800
Annu Rev Control Robot Auton Syst. 2019 May 1;2:339-364
pubmed: 31106294
Annu Rev Neurosci. 1997;20:303-30
pubmed: 9056716
Elife. 2021 Mar 01;10:
pubmed: 33647233
Brain. 2017 Dec 1;140(12):3166-3178
pubmed: 29088322
Elife. 2017 Jan 19;6:
pubmed: 28103186
Nat Neurosci. 2008 Oct;11(10):1162-7
pubmed: 18758460
Proc Natl Acad Sci U S A. 2019 Oct 22;116(43):21854-21863
pubmed: 31591217
J Neural Eng. 2011 Apr;8(2):025017
pubmed: 21436531
J Physiol. 1970 Feb;206(2):419-36
pubmed: 5498493
Elife. 2016 Jul 26;5:
pubmed: 27458796
Nature. 2021 May;593(7858):249-254
pubmed: 33981047
Brain Struct Funct. 2021 Sep;226(7):2099-2112
pubmed: 34091731
J Comp Neurol. 1984 Apr 20;224(4):591-605
pubmed: 6725633
Neuroimage. 2016 Aug 15;137:188-200
pubmed: 26707889
Nature. 2005 May 19;435(7040):300-7
pubmed: 15902248
BMC Neurosci. 2017 Jan 3;18(1):5
pubmed: 28049425
Spat Vis. 1997;10(4):433-6
pubmed: 9176952
Neuroscience. 2005;131(1):1-11
pubmed: 15680687
Exp Brain Res. 2008 Jun;188(2):223-36
pubmed: 18369608
J Neural Eng. 2012 Apr;9(2):026027
pubmed: 22427488
Trends Cogn Sci. 2017 Mar;21(3):195-204
pubmed: 28214130
Neuroimage. 2018 Apr 15;170:332-347
pubmed: 28219775
PLoS Comput Biol. 2014 Apr 17;10(4):e1003553
pubmed: 24743308
Elife. 2019 Dec 10;8:
pubmed: 31820736
Curr Biol. 2013 Mar 4;23(5):353-61
pubmed: 23416098
Sci Transl Med. 2016 Oct 19;8(361):361ra141
pubmed: 27738096
Proc Natl Acad Sci U S A. 2019 Dec 23;:
pubmed: 31871144
Sci Adv. 2020 Oct 23;6(43):
pubmed: 33097536
Neuron. 2014 Jun 18;82(6):1380-93
pubmed: 24945777
PLoS Biol. 2009 Jul;7(7):e1000153
pubmed: 19621062
J Neurosci. 2020 Nov 25;40(48):9210-9223
pubmed: 33087474