Transcriptional landscape of TRPV1, TRPA1, TRPV4, and TRPM8 channels throughout human tissues.

Humans Male Membrane Proteins / metabolism TRPA1 Cation Channel / genetics TRPM Cation Channels / genetics TRPV Cation Channels / genetics Transient Receptor Potential Channels / genetics
Bioinformatics Biomarkers Dorsal root ganglia Drug development RNA-sequencing TRP channels

Journal

Life sciences
ISSN: 1879-0631
Titre abrégé: Life Sci
Pays: Netherlands
ID NLM: 0375521

Informations de publication

Date de publication:
01 Nov 2022
Historique:
received: 06 07 2022
revised: 02 09 2022
accepted: 14 09 2022
pubmed: 21 9 2022
medline: 7 10 2022
entrez: 20 9 2022
Statut: ppublish

Résumé

This article aims to analyze the baseline distribution of TRPA1, TRPV1, TRPV4, and TRPM8 channels in human systems at the transcriptional level. Using the RNA-seq dataset from the National Center for Biotechnology Information (NCBI) gene database, we investigated and compared the transcriptional levels of TRPV1, TRPA1, TRPV4 and TRPM8 found in 95 human subjects representing 33 different tissues to determine the tissue specificity of all protein-coding genes. In this study, we observed higher transcriptional levels for TRPV1 (duodenum), TRPA1 (Urinary bladder), TRPV4 (Kidney) and TRPM8 (Prostate) compared to the other TRPs. These channels are involved in developing inflammatory and painful pathologies and seem to participate in cancer development. This information on transcriptional levels of TRPV1, TRPA1, TRPV4 and TRPM8 in human systems may provide essential suggestions for further studies on these proteins.

Identifiants

DOI: 10.1016/j.lfs.2022.120977 PMID: 36126722
pubmed: 36126722
pii: S0024-3205(22)00677-4
doi: 10.1016/j.lfs.2022.120977
pii:
doi:

Substances chimiques

Membrane Proteins 0
TRPA1 Cation Channel 0
TRPA1 protein, human 0
TRPM Cation Channels 0
TRPM8 channel-associated factor 1 protein, human 0
TRPM8 protein, human 0
TRPV Cation Channels 0
TRPV1 protein, human 0
TRPV4 protein, human 0
Transient Receptor Potential Channels 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

120977

Informations de copyright

Copyright © 2022 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Conflicts of interest The authors declare no potential conflicts of interest.

Auteurs

Sabrina Qader Kudsi (SQ)

Graduate Program in Pharmacology, Center of Health Sciences, Federal University of Santa Maria, 97105-900 Santa Maria, RS, Brazil.

Bruna Candia Piccoli (BC)

Graduate Program in Biological Sciences: Biochemistry Toxicology, Center of Natural and Exact Sciences, Federal University of Santa Maria, 97105-900 Santa Maria, RS, Brazil.

Daniel Ardisson-Araújo (D)

Laboratory of Baculovirus, Cell Biology Department, University of Brasilia, Brasília, DF 70910-900, Brazil.

Gabriela Trevisan (G)

Graduate Program in Pharmacology, Center of Health Sciences, Federal University of Santa Maria, 97105-900 Santa Maria, RS, Brazil. Electronic address: gabriela.trevisan-santos@ufsm.br.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Transcriptional landscape of TRPV1, TRPA1,...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Transcriptional landscape of TRPV1, TRPA1,...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux cationiques TRP › Membre-1 de la sous-famille A de canaux cationiques à potentiel de récepteur transitoire › Transcriptional landscape of TRPV1, TRPA1,...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux cationiques TRP › Canaux cationiques TRPM › Transcriptional landscape of TRPV1, TRPA1,...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de transport › Canaux cationiques TRPV › Transcriptional landscape of TRPV1, TRPA1,...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux cationiques TRP › Transcriptional landscape of TRPV1, TRPA1,...