Becker Muscular Dystrophy Accompanied by Anti-HMGCR Antibody-positive Immune-mediated Necrotizing Myopathy.
Becker muscular dystrophy
anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase antibody
immune-mediated necrotizing myopathy
Journal
Internal medicine (Tokyo, Japan)
ISSN: 1349-7235
Titre abrégé: Intern Med
Pays: Japan
ID NLM: 9204241
Informations de publication
Date de publication:
01 May 2023
01 May 2023
Historique:
medline:
2
5
2023
pubmed:
22
9
2022
entrez:
21
9
2022
Statut:
ppublish
Résumé
Becker muscular dystrophy (BMD) is an X-linked neuromuscular disease characterized by progressive muscle weakness that currently has no cure. Immune-mediated necrotizing myopathy (IMNM) is a type of autoimmune inflammatory myopathy characterized by proximal muscle weakness that is treated with immunosuppressive therapy. We herein report a patient diagnosed with BMD complicated with IMNM by a pathological analysis. Notably, the patient had an elevated serum anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase antibody level. Oral glucocorticoid and methotrexate treatment partially improved the muscle weakness with decreased levels of serum creatine kinase. An accurate diagnosis is important for therapeutic decisions in these complicated cases.
Identifiants
pubmed: 36130887
doi: 10.2169/internalmedicine.0202-22
pmc: PMC10208778
doi:
Substances chimiques
Autoantibodies
0
HMGCR protein, human
EC 1.1.1.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1345-1349Références
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