Selective atrophy of the cervical enlargement in whole spinal cord MRI of amyotrophic lateral sclerosis.

Humans Amyotrophic Lateral Sclerosis / diagnostic imaging Spinal Cord / diagnostic imaging Magnetic Resonance Imaging / methods Atrophy / diagnostic imaging Motor Neurons / pathology Cervical Cord / diagnostic imaging
Amyotrophic lateral sclerosis Atrophy Cervical enlargement Cross-sectional area Magnetic resonance imaging Spinal cord

Journal

NeuroImage. Clinical
ISSN: 2213-1582
Titre abrégé: Neuroimage Clin
Pays: Netherlands
ID NLM: 101597070

Informations de publication

Date de publication:
2022
Historique:
received: 31 03 2022
revised: 26 08 2022
accepted: 13 09 2022
pubmed: 23 9 2022
medline: 15 12 2022
entrez: 22 9 2022
Statut: ppublish

Résumé

Amyotrophic lateral sclerosis (ALS) is a deadly neurodegenerative disorder affecting motor neurons in the spinal cord and brain. Studies have reported on atrophy within segments of the cervical cord, but we are not aware of previous investigations of the whole spinal cord. Herein we present our findings from a 3T MRI study involving 32 subjects (15 ALS participants and 17 healthy controls) characterizing cross-sectional area along the entire cord. We report atrophy of the cervical enlargement in ALS participants, but no evidence of atrophy of the thoracolumbar enlargement. These results suggest that MR-based analyses of the cervical cord may be sufficient for in vivo investigations of spinal cord atrophy in ALS, and that atrophy of the cervical enlargement (C4-C7) is a potential imaging marker for quantifying lower motor neuron degradation.

Identifiants

DOI: 10.1016/j.nicl.2022.103199 PMID: 36137496 PMC: PMC9668597
pubmed: 36137496
pii: S2213-1582(22)00264-9
doi: 10.1016/j.nicl.2022.103199
pmc: PMC9668597
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

103199

Subventions

Organisme : NINDS NIH HHS
ID : R01 NS094306
Pays : United States
Organisme : NIBIB NIH HHS
ID : P41 EB030006
Pays : United States
Organisme : NIBIB NIH HHS
ID : R01 EB027779
Pays : United States
Organisme : NIBIB NIH HHS
ID : P41 EB015896
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS095937
Pays : United States

Informations de copyright

Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest In the past two years, J.M.H. has consulted for Amathus Therapeutics, Rodin Therapeutics, Abata Therapeutics, FogPharma, Sanofi-Aventis, Longitude Capital, and the Alzheimer’s Drug Discovery Foundation. J.M.H. is a paid Editor-in-Chief for ACS Chemical Neuroscience. J.M.H. is a co-founder and equity holder in Eikonizo Therapeutics (a license holder to J.M.H. patents) and in Sensorium Therapeutics. J.M.H. is a scientific advisory board member and equity holder in Psy Therapeutics, Delix Therapeutics, and Fuzionaire Diagnostics. J.M.H. has received sponsored research grants from Atai Life Sciences and Expesicor and has received honoraria for speaking or advisory service at non-profit academic institutions. N.A. is currently employed by Sanofi Genzyme. The other authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Robert L Barry (RL)

Athinoula A.Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA; Department of Radiology, Harvard Medical School, Boston, MA, USA; Harvard-Massachusetts Institute of Technology Health Sciences & Technology, Cambridge, MA, USA. Electronic address: Robert.Barry@mgh.Harvard.edu.

Angel Torrado-Carvajal (A)

Athinoula A.Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA; Medical Image Analysis and Biometry Laboratory, Universidad Rey Juan Carlos, Madrid, Spain.

John E Kirsch (JE)

Athinoula A.Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA; Department of Radiology, Harvard Medical School, Boston, MA, USA.

Grae E Arabasz (GE)

Athinoula A.Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA.

Daniel S Albrecht (DS)

Athinoula A.Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA.

Zeynab Alshelh (Z)

Athinoula A.Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA.

Olivia Pijanowski (O)

Sean M.Healey & AMG Center for ALS at Massachusetts General Hospital, Department of Neurology, Neurological Clinical Research Institute, Boston, MA, USA.

Austin J Lewis (AJ)

Sean M.Healey & AMG Center for ALS at Massachusetts General Hospital, Department of Neurology, Neurological Clinical Research Institute, Boston, MA, USA.

Mackenzie Keegan (M)

Sean M.Healey & AMG Center for ALS at Massachusetts General Hospital, Department of Neurology, Neurological Clinical Research Institute, Boston, MA, USA.

Beverly Reynolds (B)

Sean M.Healey & AMG Center for ALS at Massachusetts General Hospital, Department of Neurology, Neurological Clinical Research Institute, Boston, MA, USA.

Paulina C Knight (PC)

Sean M.Healey & AMG Center for ALS at Massachusetts General Hospital, Department of Neurology, Neurological Clinical Research Institute, Boston, MA, USA.

Erin J Morrissey (EJ)

Athinoula A.Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA.

Marco L Loggia (ML)

Athinoula A.Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA; Department of Radiology, Harvard Medical School, Boston, MA, USA; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA.

Nazem Atassi (N)

Sean M.Healey & AMG Center for ALS at Massachusetts General Hospital, Department of Neurology, Neurological Clinical Research Institute, Boston, MA, USA; Department of Neurology, Harvard Medical School, Boston, MA, USA; Sanofi Genzyme, Cambridge, MA, USA.

Jacob M Hooker (JM)

Athinoula A.Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA; Department of Radiology, Harvard Medical School, Boston, MA, USA.

Suma Babu (S)

Sean M.Healey & AMG Center for ALS at Massachusetts General Hospital, Department of Neurology, Neurological Clinical Research Institute, Boston, MA, USA; Department of Neurology, Harvard Medical School, Boston, MA, USA. Electronic address: sbabu@mgh.Harvard.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Selective atrophy of the cervical enlargement...
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Troubles de l'homéostasie des protéines › Protéinopathies TDP-43 › Sclérose latérale amyotrophique › Selective atrophy of the cervical enlargement...
questionsmedicales.fr › Système nerveux › Système nerveux central › Moelle spinale › Selective atrophy of the cervical enlargement...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Selective atrophy of the cervical enlargement...
questionsmedicales.fr › États, signes et symptômes pathologiques › États anatomopathologiques › Atrophie › Selective atrophy of the cervical enlargement...
questionsmedicales.fr › Cellules › Neurones › Neurones efférents › Motoneurones › Selective atrophy of the cervical enlargement...
questionsmedicales.fr › Système nerveux › Système nerveux central › Moelle spinale › Moelle cervicale › Selective atrophy of the cervical enlargement...