Incidence and Predictors of Early Death in Patients Undergoing Percutaneous Left Atrial Appendage Closure.
atrial fibrillation
death
futility
left atrial appendage closure
Journal
JACC. Clinical electrophysiology
ISSN: 2405-5018
Titre abrégé: JACC Clin Electrophysiol
Pays: United States
ID NLM: 101656995
Informations de publication
Date de publication:
Sep 2022
Sep 2022
Historique:
received:
21
03
2022
revised:
25
05
2022
accepted:
09
06
2022
entrez:
22
9
2022
pubmed:
23
9
2022
medline:
28
9
2022
Statut:
ppublish
Résumé
Left atrial appendage closure (LAAC) aims to prevent ischemic events in patients with atrial fibrillation. As a preventive procedure, early death after LAAC could render the procedure futile. The authors sought to evaluate the incidence and factors associated with early death in LAAC recipients. This was a multicenter study including consecutive patients undergoing LAAC in a 10-year period (2009-2019). Death was considered early when occurring in the first year after LAAC. A total of 807 patients (mean age 76 ± 8 years, mean CHA In this multicenter international registry, close to 1 in 6 patients died within the first year of LAAC. Older age, low body mass index, impaired estimated glomerular filtration rate, prior diabetes, and prior heart failure are independently associated with an increased risk. The risk of early death appeared to be prohibitive (∼50%) in the presence of >3 of these risk factors.
Sections du résumé
BACKGROUND
Left atrial appendage closure (LAAC) aims to prevent ischemic events in patients with atrial fibrillation. As a preventive procedure, early death after LAAC could render the procedure futile.
OBJECTIVES
The authors sought to evaluate the incidence and factors associated with early death in LAAC recipients.
METHODS
This was a multicenter study including consecutive patients undergoing LAAC in a 10-year period (2009-2019). Death was considered early when occurring in the first year after LAAC.
RESULTS
A total of 807 patients (mean age 76 ± 8 years, mean CHA
CONCLUSIONS
In this multicenter international registry, close to 1 in 6 patients died within the first year of LAAC. Older age, low body mass index, impaired estimated glomerular filtration rate, prior diabetes, and prior heart failure are independently associated with an increased risk. The risk of early death appeared to be prohibitive (∼50%) in the presence of >3 of these risk factors.
Identifiants
pubmed: 36137713
pii: S2405-500X(22)00555-2
doi: 10.1016/j.jacep.2022.06.012
pii:
doi:
Types de publication
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1093-1102Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2022 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Funding Support and Author Disclosures Dr Mesnier is supported by a research grant from the Fédération Française de Cardiologie. Dr Rodés-Cabau holds the Research Chair “Fondation Famille Jacques Larivière” for the Development of Structural Heart Disease Interventions; and has received institutional research grants from Boston Scientific. Dr Cruz-González is a proctor for Boston Scientific, Abbott, and Lifetech. Dr Nombela-Franco is a proctor for Abbott. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.