Circulating Cell-Free DNA in Renal Cell Carcinoma: The New Era of Precision Medicine.
cell-free methylated DNA
epigenetic
genetic
kidney cancer
liquid biopsy
microsatellite instability
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
07 Sep 2022
07 Sep 2022
Historique:
received:
01
08
2022
revised:
03
09
2022
accepted:
05
09
2022
entrez:
23
9
2022
pubmed:
24
9
2022
medline:
24
9
2022
Statut:
epublish
Résumé
Tumor biopsy is still the gold standard for diagnosing and prognosis renal cell carcinoma (RCC). However, its invasiveness, costs, and inability to accurately picture tumor heterogeneity represent major limitations to this procedure. Analysis of circulating cell-free DNA (cfDNA) is a non-invasive cost-effective technique that has the potential to ease cancer detection and prognosis. In particular, a growing body of evidence suggests that cfDNA could be a complementary tool to identify and prognosticate RCC while providing contemporary mutational profiling of the tumor. Further, recent research highlighted the role of cfDNA methylation profiling as a novel method for cancer detection and tissue-origin identification. This review synthesizes current knowledge on the diagnostic, prognostic, and predictive applications of cfDNA in RCC, with a specific focus on the potential role of cell-free methylated DNA (cfMeDNA).
Identifiants
pubmed: 36139519
pii: cancers14184359
doi: 10.3390/cancers14184359
pmc: PMC9497114
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
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