Sustained Increase in Serum Glial Fibrillary Acidic Protein after First ST-Elevation Myocardial Infarction.
GFAP
MRI
NfL
STEMI
cardiac magnetic resonance imaging
glial damage
glial fibrillary acidic protein
infarction size
myocardial infarction
neurofilament light chain
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
07 Sep 2022
07 Sep 2022
Historique:
received:
31
07
2022
revised:
02
09
2022
accepted:
05
09
2022
entrez:
23
9
2022
pubmed:
24
9
2022
medline:
28
9
2022
Statut:
epublish
Résumé
Acute ischemic cardiac injury predisposes one to cognitive impairment, dementia, and depression. Pathophysiologically, recent positron emission tomography data suggest astroglial activation after experimental myocardial infarction (MI). We analyzed peripheral surrogate markers of glial (and neuronal) damage serially within 12 months after the first ST-elevation MI (STEMI). Serum levels of glial fibrillary acidic protein (GFAP) and neurofilament light chain (NfL) were quantified using ultra-sensitive molecular immunoassays. Sufficient biomaterial was available from 45 STEMI patients (aged 28 to 78 years, median 56 years, 11% female). The median (quartiles) of GFAP was 63.8 (47.0, 89.9) pg/mL and of NfL 10.6 (7.2, 14.8) pg/mL at study entry 0-4 days after STEMI. GFAP after STEMI increased in the first 3 months, with a median change of +7.8 (0.4, 19.4) pg/mL (
Identifiants
pubmed: 36142218
pii: ijms231810304
doi: 10.3390/ijms231810304
pmc: PMC9499398
pii:
doi:
Substances chimiques
Biocompatible Materials
0
Biomarkers
0
Glial Fibrillary Acidic Protein
0
Neurofilament Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Federal Ministry of Education and Research
ID : 01ES0816
Organisme : Federal Ministry of Education and Research
ID : 01ES01901
Organisme : Federal Ministry of Education and Research
ID : 01ES01902
Organisme : Federal Ministry of Education and Research
ID : 01EO1004
Organisme : Deutsche Forschungsgemeinschaft
ID : 413657723
Organisme : Deutsche Forschungsgemeinschaft
ID : 453989101
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