The Effect of Uridine on the State of Skeletal Muscles and the Functioning of Mitochondria in Duchenne Dystrophy.
Animals
Calcium
/ metabolism
Disease Models, Animal
Dystrophin
/ metabolism
Mice
Mice, Inbred mdx
Mitochondria
/ metabolism
Muscle, Skeletal
/ metabolism
Muscular Dystrophy, Duchenne
/ genetics
Potassium
/ metabolism
Reactive Oxygen Species
/ metabolism
Ubiquitin-Protein Ligases
/ metabolism
Uridine
/ metabolism
Duchenne muscular dystrophy
lipid peroxidation
mitochondria
mitochondrial dysfunction
potassium transport
skeletal muscle
uridine
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
13 Sep 2022
13 Sep 2022
Historique:
received:
19
08
2022
revised:
06
09
2022
accepted:
10
09
2022
entrez:
23
9
2022
pubmed:
24
9
2022
medline:
28
9
2022
Statut:
epublish
Résumé
Duchenne muscular dystrophy is caused by the loss of functional dystrophin that secondarily causes systemic metabolic impairment in skeletal muscles and cardiomyocytes. The nutraceutical approach is considered as a possible complementary therapy for this pathology. In this work, we have studied the effect of pyrimidine nucleoside uridine (30 mg/kg/day for 28 days, i.p.), which plays an important role in cellular metabolism, on the development of DMD in the skeletal muscles of dystrophin deficient
Identifiants
pubmed: 36142572
pii: ijms231810660
doi: 10.3390/ijms231810660
pmc: PMC9500747
pii:
doi:
Substances chimiques
Dystrophin
0
Reactive Oxygen Species
0
Ubiquitin-Protein Ligases
EC 2.3.2.27
Potassium
RWP5GA015D
Calcium
SY7Q814VUP
Uridine
WHI7HQ7H85
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Russian Science Foundation
ID : 20-75-10006
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