Impact of Leptin on the Expression Profile of Macrophages during Mechanical Strain In Vitro.
Anti-Inflammatory Agents
/ pharmacology
Child
Cyclooxygenase 2
/ genetics
Humans
Inflammation Mediators
/ pharmacology
Interleukin-6
/ metabolism
Leptin
/ pharmacology
Lipopolysaccharides
/ pharmacology
Macrophages
/ metabolism
Pediatric Obesity
Porphyromonas gingivalis
/ metabolism
RNA, Messenger
Tumor Necrosis Factor-alpha
/ metabolism
inflammation
leptin
macrophages
mechanical strain
orthodontic tooth movement
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
14 Sep 2022
14 Sep 2022
Historique:
received:
21
06
2022
revised:
06
09
2022
accepted:
12
09
2022
entrez:
23
9
2022
pubmed:
24
9
2022
medline:
28
9
2022
Statut:
epublish
Résumé
Childhood obesity is a growing problem in industrial societies and associated with increased leptin levels in serum and salvia. Orthodontic treatment provokes pressure and tension zones within the periodontal ligament, where, in addition to fibroblasts, macrophages are exposed to these mechanical loadings. Given the increasing number of orthodontic patients with these conditions, insights into the effects of elevated leptin levels on the expression profile of macrophages during mechanical strain are of clinical interest. Therefore, the aim of this in vitro study was to assess the influence of leptin on the expression profile of macrophages during simulated orthodontic treatment. RAW264.7 macrophages were incubated with leptin and lipopolysaccharides (LPS) from
Identifiants
pubmed: 36142638
pii: ijms231810727
doi: 10.3390/ijms231810727
pmc: PMC9503708
pii:
doi:
Substances chimiques
Anti-Inflammatory Agents
0
Inflammation Mediators
0
Interleukin-6
0
Leptin
0
Lipopolysaccharides
0
RNA, Messenger
0
Tumor Necrosis Factor-alpha
0
Cyclooxygenase 2
EC 1.14.99.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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