Monosodium glutamate consumption reduces the renal excretion of trimethylamine N-oxide and the abundance of Akkermansia muciniphila in the gut.
Journal
Biochemical and biophysical research communications
ISSN: 1090-2104
Titre abrégé: Biochem Biophys Res Commun
Pays: United States
ID NLM: 0372516
Informations de publication
Date de publication:
19 11 2022
19 11 2022
Historique:
received:
03
09
2022
accepted:
09
09
2022
pubmed:
27
9
2022
medline:
6
10
2022
entrez:
26
9
2022
Statut:
ppublish
Résumé
We previously demonstrated that monosodium glutamate (MSG) consumption increases trimethylamine (TMA) level in the renal tissue as well as dimethylamine and methylamine levels in urine of rats, suggesting the effects of MSG on humans. To better define the findings, we investigated whether MSG consumption alters serum trimethylamine N-oxide (TMAO) level, and as a consequence, induces kidney injury in the rat model. Adult male Wistar rats (n = 40) were randomized to be fed with a standard diet (control group) or a standard diet with 0.5, 1.5 or 3.0 g% MSG corresponding to 7, 21, or 42 g/day in 60 kg man, respectively in drinking water (MSG-treated groups), or a standard diet with 3.0 g% MSG in drinking water which was withdrawn after 4 weeks (MSG-withdrawal group). Blood and urine samples were collected to analyze the TMAO levels using
Identifiants
pubmed: 36155062
pii: S0006-291X(22)01288-8
doi: 10.1016/j.bbrc.2022.09.038
pmc: PMC9851609
mid: NIHMS1864977
pii:
doi:
Substances chimiques
Dimethylamines
0
Drinking Water
0
Lipocalin-2
0
Methylamines
0
Mucins
0
trimethyloxamine
FLD0K1SJ1A
trimethylamine
LHH7G8O305
Sodium Glutamate
W81N5U6R6U
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
158-166Subventions
Organisme : NIEHS NIH HHS
ID : R35 ES030443
Pays : United States
Commentaires et corrections
Type : ErratumIn
Informations de copyright
Copyright © 2022 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors have declared that no competing interest exists.
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