Biliatresone: progress in biliary atresia study.
Biliary atresia
Biliatresone
Glutathione
Gut flora
Journal
World journal of pediatrics : WJP
ISSN: 1867-0687
Titre abrégé: World J Pediatr
Pays: Switzerland
ID NLM: 101278599
Informations de publication
Date de publication:
May 2023
May 2023
Historique:
received:
24
03
2022
accepted:
05
09
2022
medline:
2
5
2023
pubmed:
28
9
2022
entrez:
27
9
2022
Statut:
ppublish
Résumé
Biliary atresia (BA) is one of the main causes of neonatal end-stage liver disease. Without timely diagnosis and treatment, most children with BA will develop irreversible liver fibrosis within the first two months. While current theorized causes of BA include viral infection, immune disorders, and genetic defects, the comprehensive etiology is still largely unknown. Recently, biliatresone attracted much interest for its ability to induce BA in both zebrafish and mice, so we summarized the latest progress of biliatresone research in BA and tried to answer the question of whether it could provide further clues to the etiology of human BA. We conducted a PubMed search for any published articles related to the topic using search terms including "biliary atresia", "biliatresone", "GSH", and "HSP90". Relevant data were extracted from the original text or supplementary materials of the corresponding articles. Biliatresone had shown its unique toxicity in multiple species such as zebrafish and mice, and pathogenic factors involved included glutathione (GSH), heat shock protein 90 (HSP90) and the related pathways. In combination with epidemiological evidence and recent studies on the intestinal flora in biliary atresia, a new pathogenic hypothesis that the occurrence of biliary atresia is partly due to biliatresone or its structure-like compounds depositing in human body via vegetables or/and the altered intestinal flora structure can be tentatively established. Based on the existing evidence, we emphasized that GSH and HSP90 are involved in the development of BA, and the maternal diet, especially higher vegetable intake of Asian women of childbearing age, accompanied by the altered intestinal flora structure, may contribute to the occurrence of biliary atresia and the higher incidence in the Asia group. However, the evidence from large sample epidemiological research is necessary.
Sections du résumé
BACKGROUND
BACKGROUND
Biliary atresia (BA) is one of the main causes of neonatal end-stage liver disease. Without timely diagnosis and treatment, most children with BA will develop irreversible liver fibrosis within the first two months. While current theorized causes of BA include viral infection, immune disorders, and genetic defects, the comprehensive etiology is still largely unknown. Recently, biliatresone attracted much interest for its ability to induce BA in both zebrafish and mice, so we summarized the latest progress of biliatresone research in BA and tried to answer the question of whether it could provide further clues to the etiology of human BA.
DATA SOURCES
METHODS
We conducted a PubMed search for any published articles related to the topic using search terms including "biliary atresia", "biliatresone", "GSH", and "HSP90". Relevant data were extracted from the original text or supplementary materials of the corresponding articles.
RESULTS
RESULTS
Biliatresone had shown its unique toxicity in multiple species such as zebrafish and mice, and pathogenic factors involved included glutathione (GSH), heat shock protein 90 (HSP90) and the related pathways. In combination with epidemiological evidence and recent studies on the intestinal flora in biliary atresia, a new pathogenic hypothesis that the occurrence of biliary atresia is partly due to biliatresone or its structure-like compounds depositing in human body via vegetables or/and the altered intestinal flora structure can be tentatively established.
CONCLUSIONS
CONCLUSIONS
Based on the existing evidence, we emphasized that GSH and HSP90 are involved in the development of BA, and the maternal diet, especially higher vegetable intake of Asian women of childbearing age, accompanied by the altered intestinal flora structure, may contribute to the occurrence of biliary atresia and the higher incidence in the Asia group. However, the evidence from large sample epidemiological research is necessary.
Identifiants
pubmed: 36166189
doi: 10.1007/s12519-022-00619-0
pii: 10.1007/s12519-022-00619-0
pmc: PMC10149470
doi:
Substances chimiques
Glutathione
GAN16C9B8O
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
417-424Subventions
Organisme : Shanghai Key Clinical Specialty
ID : shslczdzk05703
Organisme : National Natural Science Foundation of China
ID : 81974059
Organisme : National Natural Science Foundation of China
ID : 82001595
Organisme : International Joint Laboratory Project of Haiju, National Children's Medical Center
ID : EK1125180104
Organisme : Shenkang three-year action plan of precision diagnosis and treatment project for difficult diseases
ID : SHDC2020CR2009A
Informations de copyright
© 2022. The Author(s).
Références
Harpavat S, Garcia-Prats JA, Anaya C, Brandt ML, Lupo PJ, Finegold MJ, et al. Diagnostic yield of newborn screening for biliary atresia using direct or conjugated bilirubin measurements. JAMA. 2020;323:1141–50.
pubmed: 32207797
pmcid: 7093763
doi: 10.1001/jama.2020.0837
Feldman AG, Mack CL. Biliary atresia: cellular dynamics and immune dysregulation. Semin Pediatr Surg. 2012;21:192–200.
pubmed: 22800972
pmcid: 3399127
doi: 10.1053/j.sempedsurg.2012.05.003
Lendahl U, Lui VCH, Chung PHY, Tam PKH. Biliary Atresia–emerging diagnostic and therapy opportunities. EBioMedicine. 2021;74:103689.
pubmed: 34781099
pmcid: 8604670
doi: 10.1016/j.ebiom.2021.103689
Chardot C, Carton M, Spire-Bendelac N, Le Pommelet C, Golmard JL, Auvert B. Epidemiology of biliary atresia in France: a national study 1986–96. J Hepatol. 1999;31:1006–13.
pubmed: 10604573
doi: 10.1016/S0168-8278(99)80312-2
Hsiao CH, Chang MH, Chen HL, Lee HC, Wu TC, Lin CC, et al. Universal screening for biliary atresia using an infant stool color card in Taiwan. Hepatology. 2008;47:1233–40.
pubmed: 18306391
doi: 10.1002/hep.22182
Burns J, Davenport M. Adjuvant treatments for biliary atresia. Transl Pediatr. 2020;9:253–65.
pubmed: 32775244
pmcid: 7347763
doi: 10.21037/tp.2016.10.08
Yang L, Mizuochi T, Shivakumar P, Mourya R, Luo Z, Gutta S, et al. Regulation of epithelial injury and bile duct obstruction by NLRP3, IL-1R1 in experimental biliary atresia. J Hepatol. 2018;69:1136–44.
pubmed: 29886157
pmcid: 6314850
doi: 10.1016/j.jhep.2018.05.038
Hays DM, Woolley MM, Snyder WH, Reed GB, Gwinn JL, Landing BH. Diagnosis of biliary atresia: relative accuracy of percutaneous liver biopsy, open liver biopsy, and operative cholangiography. J Pediatr. 1967;71:598–607.
pubmed: 6046627
doi: 10.1016/S0022-3476(67)80118-5
Letter AG. Cytomegalovirus and biliary atresia. Lancet. 1973;2:1206.
Tyler KL, Sokol RJ, Oberhaus SM, Le M, Karrer FM, Narkewicz MR, et al. Detection of reovirus RNA in hepatobiliary tissues from patients with extrahepatic biliary atresia and choledochal cysts. Hepatology. 1998;27:1475–82.
pubmed: 9620316
doi: 10.1002/hep.510270603
Shivakumar P, Campbell KM, Sabla GE, Miethke A, Tiao G, McNeal MM, et al. Obstruction of extrahepatic bile ducts by lymphocytes is regulated by IFN-gamma in experimental biliary atresia. J Clin Invest. 2004;114:322–9.
pubmed: 15286798
pmcid: 484981
doi: 10.1172/JCI200421153
Wang J, Xu Y, Chen Z, Liang J, Lin Z, Liang H, et al. Liver immune profiling reveals pathogenesis and therapeutics for biliary atresia. Cell. 2020;183:1867–83.e26.
pubmed: 33248023
doi: 10.1016/j.cell.2020.10.048
Wen J, Zhou Y, Wang J, Chen J, Yan W, Wu J, et al. Retraction note: interactions between Th1 cells and Tregs affect regulation of hepatic fibrosis in biliary atresia through the IFN-gamma/STAT1 pathway. Cell Death Differ. 2020;27:2295.
pubmed: 31591471
doi: 10.1038/s41418-019-0428-0
Tucker RM, Feldman AG, Fenner EK, Mack CL. Regulatory T cells inhibit Th1 cell-mediated bile duct injury in murine biliary atresia. J Hepatol. 2013;59:790–6.
pubmed: 23685050
doi: 10.1016/j.jhep.2013.05.010
Bai MR, Niu WB, Zhou Y, Gong YM, Lu YJ, Yu XX, et al. Association of common variation in ADD3 and GPC1 with biliary atresia susceptibility. Aging (Albany NY). 2020;12:7163–82.
pubmed: 32315284
doi: 10.18632/aging.103067
Smith K. Biliary tract: GPC1 genetic risk further links Hedgehog signalling with pathogenesis of biliary atresia. Nat Rev Gastroenterol Hepatol. 2013;10:127.
pubmed: 23381191
doi: 10.1038/nrgastro.2013.20
Davenport M. Biliary atresia: from Australia to the zebrafish. J Pediatr Surg. 2016;51:200–5.
pubmed: 26653951
doi: 10.1016/j.jpedsurg.2015.10.058
Patman G. Biliary tract: newly identified biliatresone causes biliary atresia. Nat Rev Gastroenterol Hepatol. 2015;12:369.
pubmed: 26008130
doi: 10.1038/nrgastro.2015.91
Joest E. Handbook of special pathological anatomy of domestic animals. 3rd ed. Paul Parey; 1949.
Harper P, Plant JW, Unger DB. Congenital biliary atresia and jaundice in lambs and calves. Aust Vet J. 1990;67:18–22.
pubmed: 2334368
doi: 10.1111/j.1751-0813.1990.tb07385.x
Lemaigre FP. Development of the intrahepatic and extrahepatic biliary tract: a framework for understanding congenital diseases. Ann Rev Pathol. 2020;15:1–22.
doi: 10.1146/annurev-pathmechdis-012418-013013
Lorent K, Gong W, Koo KA, Waisbourd-Zinman O, Karjoo S, Zhao X, et al. Identification of a plant isoflavonoid that causes biliary atresia. Sci Transl Med. 2015;7:286.
doi: 10.1126/scitranslmed.aaa1652
Koo KA, Lorent K, Gong W, Windsor P, Whittaker SJ, Pack M, et al. Biliatresone, a reactive natural toxin from Dysphania glomulifera and D. littoralis: discovery of the toxic moiety 1,2-diaryl-2-propenone. Chem Res Toxicol. 2015;28:1519–21.
pubmed: 26175131
pmcid: 4755499
doi: 10.1021/acs.chemrestox.5b00227
Koo KA, Waisbourd-Zinman O, Wells RG, Pack M, Porter JR. Reactivity of biliatresone, a natural biliary toxin, with glutathione, histamine, and amino acids. Chem Res Toxicol. 2016;29:142–9.
pubmed: 26713899
pmcid: 4757443
doi: 10.1021/acs.chemrestox.5b00308
Estrada MA, Zhao X, Lorent K, Kriegermeier A, Nagao SA, Berritt S, et al. Synthesis and structure-activity relationship study of biliatresone, a plant isoflavonoid that causes biliary atresia. ACS Med Chem Lett. 2017;9:61–4.
pubmed: 29348813
pmcid: 5767885
doi: 10.1021/acsmedchemlett.7b00479
Yang Y, Dong R, Jia L, Qiang L, Shan Z. Synthesis study of biliatresone, a plant isoflavonoid that causes biliary atresia in zebrafish. Chin J Exp Surg. 2019;36:3 (in Chinese).
Pal N, Joy PS, Sergi CM. Biliary atresia animal models: is the needle in a haystack? Int J Mol Sci. 2022;23:7838.
pubmed: 35887185
pmcid: 9324346
doi: 10.3390/ijms23147838
Zhao X, Lorent K, Escobar-Zarate D, Rajagopalan R, Loomes KM, Gillespie K, et al. Impaired redox and protein homeostasis as risk factors and therapeutic targets in toxin-induced biliary atresia. Gastroenterology. 2020;159:1068–84.e2.
pubmed: 32505743
doi: 10.1053/j.gastro.2020.05.080
Yang Y, Wang J, Zhan Y, Chen G, Shen Z, Zheng S, et al. The synthetic toxin biliatresone causes biliary atresia in mice. Lab Invest. 2020;100:1425–35.
pubmed: 32681026
doi: 10.1038/s41374-020-0467-7
Thomas H. Biliary tract: MMP7–a diagnostic biomarker for biliary atresia. Nat Rev Gastroenterol Hepatol. 2018;15:68.
pubmed: 29235550
doi: 10.1038/nrgastro.2017.175
Iwanami N, Hess I, Schorpp M, Boehm T. Studying the adaptive immune system in zebrafish by transplantation of hematopoietic precursor cells. Methods Cell Biol. 2017;138:151–61.
pubmed: 28129842
doi: 10.1016/bs.mcb.2016.08.003
Cao P, Sun J, Sullivan MA, Huang X, Wang H, Zhang Y, et al. Angelica sinensis polysaccharide protects against acetaminophen-induced acute liver injury and cell death by suppressing oxidative stress and hepatic apoptosis in vivo and in vitro. Int J Biol Macromol. 2018;111:1133–9.
pubmed: 29415408
doi: 10.1016/j.ijbiomac.2018.01.139
Ali FEM, Bakr AG, Abo-Youssef AM, Azouz AA, Hemeida RAM. Targeting Keap-1/Nrf-2 pathway and cytoglobin as a potential protective mechanism of diosmin and pentoxifylline against cholestatic liver cirrhosis. Life Sci. 2018;207:50–60.
pubmed: 29852187
doi: 10.1016/j.lfs.2018.05.048
Luo Z, Shivakumar P, Mourya R, Gutta S, Bezerra JA. Gene expression signatures associated with survival times of pediatric patients with biliary atresia identify potential therapeutic agents. Gastroenterology. 2019;157:1138–52.e14.
pubmed: 31228442
doi: 10.1053/j.gastro.2019.06.017
Wang J, Xu J, Xia M, Yang Y, Shen Z, Chen G, et al. Correlation between hepatic oxidative damage and clinical severity and mitochondrial gene sequencing results in biliary atresia. Hepatol Res. 2019;49:695–704.
pubmed: 30811072
doi: 10.1111/hepr.13324
Zhao X, Lorent K, Wilkins BJ, Marchione DM, Gillespie K, Waisbourd-Zinman O, et al. Glutathione antioxidant pathway activity and reserve determine toxicity and specificity of the biliary toxin biliatresone in zebrafish. Hepatology. 2016;64:894–907.
pubmed: 27102575
doi: 10.1002/hep.28603
Merino-Azpitarte M, Lozano E, Perugorria MJ, Esparza-Baquer A, Erice O, Santos-Laso A, et al. SOX17 regulates cholangiocyte differentiation and acts as a tumor suppressor in cholangiocarcinoma. J Hepatol. 2017;67:72–83.
pubmed: 28237397
pmcid: 5502751
doi: 10.1016/j.jhep.2017.02.017
Bock C, Boutros M, Camp JG, Clarke L, Clevers H, Knoblich JA, et al. The organoid cell atlas. Nat Biotechnol. 2021;39:13–7.
pubmed: 33384458
doi: 10.1038/s41587-020-00762-x
Waisbourd-Zinman O, Koh H, Tsai S, Lavrut PM, Dang C, Zhao X, et al. The toxin biliatresone causes mouse extrahepatic cholangiocyte damage and fibrosis through decreased glutathione and SOX17. Hepatology. 2016;64:880–93.
pubmed: 27081925
doi: 10.1002/hep.28599
Krneta-Stankic V, Corkins ME, Paulucci-Holthauzen A, Kloc M, Gladden AB, Miller RK. The Wnt/PCP formin Daam1 drives cell-cell adhesion during nephron development. Cell Rep. 2021;36:109340.
pubmed: 34233186
pmcid: 8629027
doi: 10.1016/j.celrep.2021.109340
Wang DP, Tang XZ, Liang QK, Zeng XJ, Yang JB, Xu J. MicroRNA-599 promotes apoptosis and represses proliferation and epithelial-mesenchymal transition of papillary thyroid carcinoma cells via downregulation of Hey2-depentent Notch signaling pathway. J Cell Physiol. 2020;235:2492–505.
pubmed: 31565805
doi: 10.1002/jcp.29154
Fried S, Gilboa D, Har-Zahav A, Lavrut PM, Du Y, Karjoo S, et al. Extrahepatic cholangiocyte obstruction is mediated by decreased glutathione, Wnt and Notch signaling pathways in a toxic model of biliary atresia. Sci Rep. 2020;10:7599.
pubmed: 32371929
pmcid: 7200694
doi: 10.1038/s41598-020-64503-5
Schopf FH, Biebl MM, Buchner J. The HSP90 chaperone machinery. Nat Rev Mol Cell Biol. 2017;18:345–60.
pubmed: 28429788
doi: 10.1038/nrm.2017.20
Moran Luengo T, Mayer MP, Rudiger SGD. The Hsp70-Hsp90 chaperone cascade in protein folding. Trends Cell Biol. 2019;29:164–77.
pubmed: 30502916
doi: 10.1016/j.tcb.2018.10.004
Rajagopalan R, Tsai EA, Grochowski CM, Kelly SM, Loomes KM, Spinner NB, et al. Exome sequencing in individuals with isolated biliary atresia. Sci Rep. 2020;10:2709.
pubmed: 32066793
pmcid: 7026070
doi: 10.1038/s41598-020-59379-4
Dong R, Deng P, Huang Y, Shen C, Xue P, Zheng S. Identification of HSP90 as potential biomarker of biliary atresia using two-dimensional electrophoresis and mass spectrometry. PLoS One. 2013;8:e68602.
pubmed: 23874684
pmcid: 3708914
doi: 10.1371/journal.pone.0068602
Elliger CA, Halloin JM. Phenolics induced in beta vulgaris by Rhizoctonia solani infection. Phytochemistry. 1994;37:691–3.
pubmed: 7765684
doi: 10.1016/S0031-9422(00)90340-6
Geigert J, Stermitz FR, Johnson G, Maag DD, Johnson DK. Two phytoalexins from sugarbeet (Beta vulgaris) leaves. Tetrahedron. 1973;29:2703–6.
doi: 10.1016/S0040-4020(01)93389-7
Hur HG, Beger RD, Heinze TM, Lay JO Jr, Freeman JP, Dore J, et al. Isolation of an anaerobic intestinal bacterium capable of cleaving the C-ring of the isoflavonoid daidzein. Arch Microbiol. 2002;178:8–12.
pubmed: 12070764
doi: 10.1007/s00203-002-0414-6
Tripathi A, Debelius J, Brenner DA, Karin M, Loomba R, Schnabl B, et al. The gut-liver axis and the intersection with the microbiome. Nat Rev Gastroenterol Hepatol. 2018;15:397–411.
pubmed: 29748586
pmcid: 6319369
doi: 10.1038/s41575-018-0011-z
Albillos A, de Gottardi A, Rescigno M. The gut-liver axis in liver disease: pathophysiological basis for therapy. J Hepatol. 2020;72:558–77.
pubmed: 31622696
doi: 10.1016/j.jhep.2019.10.003
Song W, Sun LY, Zhu ZJ, Wei L, Qu W, Zeng ZG, et al. Association of gut microbiota and metabolites with disease progression in children with biliary atresia. Front Immunol. 2021;12:698900.
pubmed: 34630385
pmcid: 8495239
doi: 10.3389/fimmu.2021.698900
Yang T, Yang S, Zhao J, Wang P, Li S, Jin Y, et al. Comprehensive analysis of gut microbiota and fecal bile acid profiles in children with biliary atresia. Front Cell Infect Microbiol. 2022;12:914247.
pubmed: 35782134
pmcid: 9247268
doi: 10.3389/fcimb.2022.914247
van Wessel D, Nomden M, Bruggink J, de Kleine R, Kurilshikov A, Verkade H, et al. Gut microbiota composition of biliary atresia patients before Kasai portoenterostomy associates with long-term outcome. J Pediatr Gastroenterol Nutr. 2021;73:485–90.
pubmed: 34269330
pmcid: 8448407
doi: 10.1097/MPG.0000000000003234
Wang J, Qian T, Jiang J, Yang Y, Shen Z, Huang Y, et al. Gut microbial profile in biliary atresia: a case-control study. J Gastroenterol Hepatol. 2020;35:334–42.
pubmed: 31271681
doi: 10.1111/jgh.14777
Jee JJ, Yang L, Shivakumar P, Xu PP, Mourya R, Thanekar U, et al. Maternal regulation of biliary disease in neonates via gut microbial metabolites. Nat Commun. 2022;13:18.
pubmed: 35013245
pmcid: 8748778
doi: 10.1038/s41467-021-27689-4
Chung PHY, Zheng S, Tam PKH. Biliary atresia: east versus west. Semin Pediatr Surg. 2020;29:150950.
pubmed: 32861448
doi: 10.1016/j.sempedsurg.2020.150950
Hopkins PC, Yazigi N, Nylund CM. Incidence of biliary atresia and timing of hepatoportoenterostomy in the United States. J Pediatr. 2017;187:253–7.
pubmed: 28746031
doi: 10.1016/j.jpeds.2017.05.006
GBD 2017 Diet Collaborators. Health effects of dietary risks in 195 countries, 1990–2017: a systematic analysis for the global burden of disease study 2017. Lancet. 2019;393:1958–72.
doi: 10.1016/S0140-6736(19)30041-8
Lock K, Pomerleau J, Causer L, Altmann DR, McKee M. The global burden of disease attributable to low consumption of fruit and vegetables: implications for the global strategy on diet. Bull World Health Organ. 2005;83:100–8.
pubmed: 15744402
pmcid: 2623811
The NS, Honein MA, Caton AR, Moore CA, Siega-Riz AM, Druschel CM, et al. Risk factors for isolated biliary atresia, national birth defects prevention study, 1997–2002. Am J Med Genet A. 2007;143A:2274–84.
pubmed: 17726689
doi: 10.1002/ajmg.a.31926
Zhao D, Gong X, Li Y, Sun X, Chen Y, Deng Z, et al. Effects of cytomegalovirus infection on the differential diagnosis between biliary atresia and intrahepatic cholestasis in a Chinese large cohort study. Ann Hepatol. 2021;23:100286.
pubmed: 33189910
doi: 10.1016/j.aohep.2020.100286
Davenport M, Muntean A, Hadzic N. Biliary atresia: clinical phenotypes and aetiological heterogeneity. J Clin Med. 2021;10:5675.
pubmed: 34884377
pmcid: 8658215
doi: 10.3390/jcm10235675
Shen O, Sela HY, Nagar H, Rabinowitz R, Jacobovich E, Chen D, et al. Prenatal diagnosis of biliary atresia: a case series. Early Hum Dev. 2017;111:16–9.
pubmed: 28531808
doi: 10.1016/j.earlhumdev.2017.05.005
Chen L, He F, Zeng K, Wang B, Li J, Zhao D, et al. Differentiation of cystic biliary atresia and choledochal cysts using prenatal ultrasonography. Ultrasonography. 2022;41:140–9.
pubmed: 34187150
doi: 10.14366/usg.21028
Harpavat S, Finegold MJ, Karpen SJ. Patients with biliary atresia have elevated direct/conjugated bilirubin levels shortly after birth. Pediatrics. 2011;128:e1428–33.
pubmed: 22106076
pmcid: 3387898
doi: 10.1542/peds.2011-1869