Drug transporters are implicated in the diffusion of tacrolimus into the T lymphocyte in kidney and liver transplant recipients: Genetic, mRNA, protein expression, and functionality.
Drug transporter
Personalized medicine
Pharmacokinetics
Solid organ transplantation
Tacrolimus
Therapeutic drug monitoring
Journal
Drug metabolism and pharmacokinetics
ISSN: 1880-0920
Titre abrégé: Drug Metab Pharmacokinet
Pays: England
ID NLM: 101164773
Informations de publication
Date de publication:
Dec 2022
Dec 2022
Historique:
received:
16
05
2022
revised:
03
08
2022
accepted:
11
08
2022
pubmed:
28
9
2022
medline:
6
12
2022
entrez:
27
9
2022
Statut:
ppublish
Résumé
Because of a narrow therapeutic index and a wide inter- and intra-patient variability, therapeutic drug monitoring of the immunosuppressant drug tacrolimus (TAC) based on whole-blood concentrations (C
Identifiants
pubmed: 36166890
pii: S1347-4367(22)00030-1
doi: 10.1016/j.dmpk.2022.100473
pii:
doi:
Substances chimiques
Tacrolimus
WM0HAQ4WNM
RNA, Messenger
0
Cytochrome P-450 CYP3A
EC 1.14.14.1
Immunosuppressive Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
100473Informations de copyright
Copyright © 2022 The Japanese Society for the Study of Xenobiotics. Published by Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest Gwendal Coste's Ph.D. has been partly funded by Astellas Pharma. Florian Lemaitre has been invited to participation in congresses by Chiesi and Sandoz.