The role of the dystrophin glycoprotein complex in muscle cell mechanotransduction.
Journal
Communications biology
ISSN: 2399-3642
Titre abrégé: Commun Biol
Pays: England
ID NLM: 101719179
Informations de publication
Date de publication:
27 09 2022
27 09 2022
Historique:
received:
01
05
2022
accepted:
12
09
2022
entrez:
28
9
2022
pubmed:
29
9
2022
medline:
30
9
2022
Statut:
epublish
Résumé
Dystrophin is the central protein of the dystrophin-glycoprotein complex (DGC) in skeletal and heart muscle cells. Dystrophin connects the actin cytoskeleton to the extracellular matrix (ECM). Severing the link between the ECM and the intracellular cytoskeleton has a devastating impact on the homeostasis of skeletal muscle cells, leading to a range of muscular dystrophies. In addition, the loss of a functional DGC leads to progressive dilated cardiomyopathy and premature death. Dystrophin functions as a molecular spring and the DGC plays a critical role in maintaining the integrity of the sarcolemma. Additionally, evidence is accumulating, linking the DGC to mechanosignalling, albeit this role is still less understood. This review article aims at providing an up-to-date perspective on the DGC and its role in mechanotransduction. We first discuss the intricate relationship between muscle cell mechanics and function, before examining the recent research for a role of the dystrophin glycoprotein complex in mechanotransduction and maintaining the biomechanical integrity of muscle cells. Finally, we review the current literature to map out how DGC signalling intersects with mechanical signalling pathways to highlight potential future points of intervention, especially with a focus on cardiomyopathies.
Identifiants
pubmed: 36168044
doi: 10.1038/s42003-022-03980-y
pii: 10.1038/s42003-022-03980-y
pmc: PMC9515174
doi:
Substances chimiques
Dystrophin
0
Glycoproteins
0
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1022Subventions
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/S001123/1
Pays : United Kingdom
Organisme : British Heart Foundation
ID : PG/20/6/34835
Pays : United Kingdom
Organisme : British Heart Foundation
ID : FS/18/64/34185
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : R01 HL146514
Pays : United States
Informations de copyright
© 2022. The Author(s).
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