Synthesis and structure-activity relationship of berkeleylactone A-derived antibiotics.

Anti-Bacterial Agents / pharmacology Macrolides Methicillin Methicillin-Resistant Staphylococcus aureus Microbial Sensitivity Tests Staphylococcus aureus Structure-Activity Relationship

Journal

Organic & biomolecular chemistry
ISSN: 1477-0539
Titre abrégé: Org Biomol Chem
Pays: England
ID NLM: 101154995

Informations de publication

Date de publication:
12 10 2022
Historique:
pubmed: 29 9 2022
medline: 14 10 2022
entrez: 28 9 2022
Statut: epublish

Résumé

Berkeleylactone A is a potent 16-membered macrolactone antibiotic, recently isolated from a coculture of Berkeley Pit Lake fungi. Although its antimicrobial activity has already been investigated, little is known about the structure-activity relationship. Based on our previous synthetic studies, a series of berkeleylactone A derivatives were synthesized and evaluated for their

Identifiants

DOI: 10.1039/d2ob01452a PMID: 36169622
pubmed: 36169622
doi: 10.1039/d2ob01452a
doi:

Substances chimiques

Anti-Bacterial Agents 0
Macrolides 0
berkeleylactone A 0
Methicillin Q91FH1328A

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

7821-7832

Auteurs

Tomáš Malatinský (T)

Institute of Organic Chemistry, Catalysis and Petrochemistry, Slovak University of Technology, Radlinského 9, 812 37 Bratislava, Slovakia. olga.caletkova@stuba.sk.

Dominika Valachová (D)

Institute of Organic Chemistry, Catalysis and Petrochemistry, Slovak University of Technology, Radlinského 9, 812 37 Bratislava, Slovakia. olga.caletkova@stuba.sk.

Lucia Pinčeková (L)

Institute of Organic Chemistry, Catalysis and Petrochemistry, Slovak University of Technology, Radlinského 9, 812 37 Bratislava, Slovakia. olga.caletkova@stuba.sk.

David Scherhaufer (D)

Institute of Organic Chemistry, Catalysis and Petrochemistry, Slovak University of Technology, Radlinského 9, 812 37 Bratislava, Slovakia. olga.caletkova@stuba.sk.

Petra Olejníková (P)

Institute of Biochemistry and Microbiology, Slovak University of Technology, Radlinského 9, 812 37 Bratislava, Slovakia.

Magdaléna Májeková (M)

Institute of Experimental Pharmacology & Toxicology, Centre of Experimental Medicine SAS, Dúbravská cesta 9, 841 04 Bratislava, Slovakia.

Jarmila Vargová (J)

Department of Microbiology and Virology, Faculty of Natural Sciences, Comenius University in Bratislava, Mlynská dolina, Ilkovičova 6, 842 15 Bratislava, Slovakia.

Barbora Gaálová-Radochová (B)

Department of Microbiology and Virology, Faculty of Natural Sciences, Comenius University in Bratislava, Mlynská dolina, Ilkovičova 6, 842 15 Bratislava, Slovakia.

Helena Bujdáková (H)

Department of Microbiology and Virology, Faculty of Natural Sciences, Comenius University in Bratislava, Mlynská dolina, Ilkovičova 6, 842 15 Bratislava, Slovakia.

Jana Nováčiková (J)

Central Laboratories, Slovak University of Technology, Radlinského 9, 812 37 Bratislava, Slovakia.

Alistair J M Farley (AJM)

The Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK.

Dušan Berkeš (D)

Institute of Organic Chemistry, Catalysis and Petrochemistry, Slovak University of Technology, Radlinského 9, 812 37 Bratislava, Slovakia. olga.caletkova@stuba.sk.
ORCID: 0000-0002-5717-5763

Pavol Jakubec (P)

Institute of Organic Chemistry, Catalysis and Petrochemistry, Slovak University of Technology, Radlinského 9, 812 37 Bratislava, Slovakia. olga.caletkova@stuba.sk.

Andrej Kolarovič (A)

Department of Chemistry, Faculty of Education, Trnava University, Priemyselná 4, 918 43 Trnava, Slovakia.
ORCID: 0000-0001-8533-0743

Oľga Caletková (O)

Institute of Organic Chemistry, Catalysis and Petrochemistry, Slovak University of Technology, Radlinského 9, 812 37 Bratislava, Slovakia. olga.caletkova@stuba.sk.
ORCID: 0000-0001-6296-7266

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Synthesis and structure-activity relationship...
questionsmedicales.fr › Composés polycycliques › Composés macrocycliques › Polycétides › Macrolides › Synthesis and structure-activity relationship...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › bêta-Lactames › Pénicillines › Méticilline › Synthesis and structure-activity relationship...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Cocci à Gram positif › Staphylococcaceae › Staphylococcus › Staphylococcus aureus › Staphylococcus aureus résistant à la méticilline › Synthesis and structure-activity relationship...
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Tests de sensibilité microbienne › Synthesis and structure-activity relationship...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Cocci à Gram positif › Staphylococcaceae › Staphylococcus › Staphylococcus aureus › Synthesis and structure-activity relationship...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Synthesis and structure-activity relationship...