CRISPR screens in Drosophila cells identify Vsg as a Tc toxin receptor.

Animals Bacterial Toxins / metabolism Biological Control Agents CRISPR-Cas Systems Culicidae Drosophila Proteins / genetics Drosophila melanogaster / cytology Fat Body / cytology Gene Editing Gene Knockdown Techniques Hemocytes Humans Moths Mucins Pest Control, Biological Phagocytosis Photorhabdus / metabolism Repetitive Sequences, Amino Acid Transgenes Virulence Factors / metabolism

Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
10 2022
Historique:
received: 08 09 2021
accepted: 18 08 2022
pubmed: 29 9 2022
medline: 15 10 2022
entrez: 28 9 2022
Statut: ppublish

Résumé

Entomopathogenic nematodes are widely used as biopesticides

Identifiants

DOI: 10.1038/s41586-022-05250-7 PMID: 36171290 PMC: PMC9631961
pubmed: 36171290
doi: 10.1038/s41586-022-05250-7
pii: 10.1038/s41586-022-05250-7
pmc: PMC9631961
mid: NIHMS1835504
doi:

Substances chimiques

Bacterial Toxins 0
Biological Control Agents 0
Drosophila Proteins 0
Mucins 0
Virulence Factors 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

349-355

Subventions

Organisme : NINDS NIH HHS
ID : R01 NS080833
Pays : United States
Organisme : NIGMS NIH HHS
ID : P41 GM132087
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS117626
Pays : United States
Organisme : Howard Hughes Medical Institute
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI170835
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK034854
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI139087
Pays : United States
Organisme : NICHD NIH HHS
ID : P30 HD018655
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI132387
Pays : United States

Informations de copyright

© 2022. The Author(s), under exclusive licence to Springer Nature Limited.

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Auteurs

Ying Xu (Y)

Department of Urology, Boston Children's Hospital, Boston, MA, USA.
Department of Surgery and Department of Microbiology, Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0002-8888-786X

Raghuvir Viswanatha (R)

Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA.

Oleg Sitsel (O)

Department of Structural Biochemistry, Max Planck Institute of Molecular Physiology, Dortmund, Germany.
ORCID: 0000-0002-4496-7489

Daniel Roderer (D)

Department of Structural Biochemistry, Max Planck Institute of Molecular Physiology, Dortmund, Germany.
Section of Structural Biology, Leibniz-Forschungsinstitut für Molekulare Pharmakologie, Berlin, Germany.
ORCID: 0000-0002-7276-3467

Haifang Zhao (H)

Jiangsu Key Laboratory of Biological Cancer, Cancer Institute, Xuzhou Medical University, Xuzhou, China.

Christopher Ashwood (C)

Department of Surgery, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.
Beth Israel Deaconess Medical Center Glycomics Core, Boston, MA, USA.

Cecilia Voelcker (C)

Beth Israel Deaconess Medical Center Glycomics Core, Boston, MA, USA.

Songhai Tian (S)

Department of Urology, Boston Children's Hospital, Boston, MA, USA.
Department of Surgery and Department of Microbiology, Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0001-6630-1904

Stefan Raunser (S)

Department of Structural Biochemistry, Max Planck Institute of Molecular Physiology, Dortmund, Germany. stefan.raunser@mpi-dortmund.mpg.de.
ORCID: 0000-0001-9373-3016

Norbert Perrimon (N)

Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA. perrimon@genetics.med.harvard.edu.
Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA. perrimon@genetics.med.harvard.edu.
ORCID: 0000-0001-7542-472X

Min Dong (M)

Department of Urology, Boston Children's Hospital, Boston, MA, USA. min.dong@childrens.harvard.edu.
Department of Surgery and Department of Microbiology, Harvard Medical School, Boston, MA, USA. min.dong@childrens.harvard.edu.
ORCID: 0000-0002-1744-7293

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › CRISPR screens in Drosophila cells identify...
questionsmedicales.fr › Facteurs biologiques › Toxines biologiques › Toxines bactériennes › CRISPR screens in Drosophila cells identify...
questionsmedicales.fr › Mélanges complexes › Produits biologiques › Agents de lutte biologique › CRISPR screens in Drosophila cells identify...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Extinction de l'expression des gènes › Systèmes CRISPR-Cas › CRISPR screens in Drosophila cells identify...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Arthropodes › Insectes › Pterygota › Neoptera › Holometabola › Diptera › Nematocera › Culicomorpha › Culicidae › CRISPR screens in Drosophila cells identify...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines d'arthropode › Protéines d'insecte › Protéines de Drosophila › CRISPR screens in Drosophila cells identify...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Arthropodes › Insectes › Pterygota › Neoptera › Holometabola › Diptera › Drosophilidae › Drosophila › Drosophila melanogaster › CRISPR screens in Drosophila cells identify...
questionsmedicales.fr › Structures anatomiques de l'animal › Corps gras › CRISPR screens in Drosophila cells identify...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Génie génétique › Édition de gène › CRISPR screens in Drosophila cells identify...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Ciblage de gène › Techniques de knock-down de gènes › CRISPR screens in Drosophila cells identify...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Sang › Cellules sanguines › Hémocytes › CRISPR screens in Drosophila cells identify...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › CRISPR screens in Drosophila cells identify...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Arthropodes › Insectes › Pterygota › Neoptera › Holometabola › Lepidoptera › Papillons de nuit › CRISPR screens in Drosophila cells identify...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Glycoprotéines › Mucoprotéines › Mucines › CRISPR screens in Drosophila cells identify...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Pratiques en santé publique › Contrôle des maladies transmissibles › Lutte contre les nuisibles › Lutte biologique contre les nuisibles › CRISPR screens in Drosophila cells identify...
questionsmedicales.fr › Phénomènes du système immunitaire › Phagocytose › CRISPR screens in Drosophila cells identify...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Enterobacteriaceae › Photorhabdus › CRISPR screens in Drosophila cells identify...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Éléments structuraux des protéines › Séquences répétées d'acides aminés › CRISPR screens in Drosophila cells identify...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Transgènes › CRISPR screens in Drosophila cells identify...
questionsmedicales.fr › Facteurs biologiques › Toxines biologiques › Facteurs de virulence › CRISPR screens in Drosophila cells identify...