Structure-based discovery of nonopioid analgesics acting through the α
Journal
Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511
Informations de publication
Date de publication:
30 09 2022
30 09 2022
Historique:
entrez:
29
9
2022
pubmed:
30
9
2022
medline:
4
10
2022
Statut:
ppublish
Résumé
Because nonopioid analgesics are much sought after, we computationally docked more than 301 million virtual molecules against a validated pain target, the α
Identifiants
pubmed: 36173843
doi: 10.1126/science.abn7065
pmc: PMC10360211
mid: NIHMS1863177
doi:
Substances chimiques
Adrenergic alpha-2 Receptor Agonists
0
Analgesics, Non-Narcotic
0
Ligands
0
Dexmedetomidine
67VB76HONO
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
eabn7065Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM133836
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM122481
Pays : United States
Organisme : NINDS NIH HHS
ID : R35 NS097306
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM008284
Pays : United States
Commentaires et corrections
Type : CommentIn
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